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Difference between revisions of "Glioblastoma"
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→Molecular: +chr7/-10
Jensflorian (talk | contribs) (→Molecular: wikify + ref) |
Jensflorian (talk | contribs) (→Molecular: +chr7/-10) |
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** In cases above 55 years, negative IDH1 R132H immunohistochemistry may be sufficient. | ** In cases above 55 years, negative IDH1 R132H immunohistochemistry may be sufficient. | ||
* 70% of IDH-wildtype glioblastoma show chr.7 gain and chr.10 loss.<ref>{{Cite journal | last1 = Ceccarelli | first1 = M. | last2 = Barthel | first2 = FP. | last3 = Malta | first3 = TM. | last4 = Sabedot | first4 = TS. | last5 = Salama | first5 = SR. | last6 = Murray | first6 = BA. | last7 = Morozova | first7 = O. | last8 = Newton | first8 = Y. | last9 = Radenbaugh | first9 = A. | title = Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. | journal = Cell | volume = 164 | issue = 3 | pages = 550-63 | month = Jan | year = 2016 | doi = 10.1016/j.cell.2015.12.028 | PMID = 26824661 }}</ref> | |||
*Seen in inherited tumor syndromes: | *Seen in inherited tumor syndromes: | ||
**[[Lynch syndrome]] | **[[Lynch syndrome]] | ||