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Difference between revisions of "Meningioma"
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→Prognosis: factors
Jensflorian (talk | contribs) (→Metaplastic meningioma: images added) |
Jensflorian (talk | contribs) (→Prognosis: factors) |
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**Metastases are rare and then usu. after surgery. | **Metastases are rare and then usu. after surgery. | ||
*May be malignant - bad prognosis. | *May be malignant - bad prognosis. | ||
*Factors associated with unfavourable prognosis: | |||
**BAP1 mutations.<ref>{{Cite journal | last1 = Shankar | first1 = GM. | last2 = Abedalthagafi | first2 = M. | last3 = Vaubel | first3 = RA. | last4 = Merrill | first4 = PH. | last5 = Nayyar | first5 = N. | last6 = Gill | first6 = CM. | last7 = Brewster | first7 = R. | last8 = Bi | first8 = WL. | last9 = Agarwalla | first9 = PK. | title = Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. | journal = Neuro Oncol | volume = 19 | issue = 4 | pages = 535-545 | month = 04 | year = 2017 | doi = 10.1093/neuonc/now235 | PMID = 28170043 }}</ref> | |||
**Presence of TERT promotor mutation.<ref>{{Cite journal | last1 = Sahm | first1 = F. | last2 = Schrimpf | first2 = D. | last3 = Olar | first3 = A. | last4 = Koelsche | first4 = C. | last5 = Reuss | first5 = D. | last6 = Bissel | first6 = J. | last7 = Kratz | first7 = A. | last8 = Capper | first8 = D. | last9 = Schefzyk | first9 = S. | title = TERT Promoter Mutations and Risk of Recurrence in Meningioma. | journal = J Natl Cancer Inst | volume = 108 | issue = 5 | pages = | month = May | year = 2016 | doi = 10.1093/jnci/djv377 | PMID = 26668184 }}</ref> | |||
**Loss of H3K27me3.<ref>{{Cite journal | last1 = Katz | first1 = LM. | last2 = Hielscher | first2 = T. | last3 = Liechty | first3 = B. | last4 = Silverman | first4 = J. | last5 = Zagzag | first5 = D. | last6 = Sen | first6 = R. | last7 = Wu | first7 = P. | last8 = Golfinos | first8 = JG. | last9 = Reuss | first9 = D. | title = Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence. | journal = Acta Neuropathol | volume = | issue = | pages = | month = Apr | year = 2018 | doi = 10.1007/s00401-018-1844-9 | PMID = 29627952 }}</ref> | |||
===Genetics=== | ===Genetics=== | ||