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Difference between revisions of "Estrogen receptor"
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Undo revision 48550 by Jensflorian (talk) -sorry
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{{ Infobox immunostain | {{ Infobox immunostain | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Stomach Metastatic Breast Carcinoma, IHC for Estrogen Receptor (5610737866).jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = ER+ve in metastatic breast carcinoma. | ||
| Abbrev = | | Abbrev = ER | ||
| Synonyms = | | Synonyms = | ||
| Similar = | | Similar = | ||
| Line 11: | Line 11: | ||
| Subspecial = | | Subspecial = | ||
| Pattern = nuclear staining | | Pattern = nuclear staining | ||
| Positive = Breast carcinoma | | Positive = Breast and endometrial carcinoma | ||
| Negative = | | Negative = | ||
| Other = | | Other = | ||
}} | }} | ||
''' | '''Estrogen receptor''', abbreviated '''ER''', is a common [[immunostain]]. | ||
==General== | ==General== | ||
*Nuclear stain. | *Nuclear stain - like most other "p" stains. | ||
*In the context of breast pathology it is a [[Quality#Classification_of_IHC_tests|class II IHC test]], as it is used for treatment decisions by itself.<ref name=pmid20154273>{{Cite journal | last1 = Torlakovic | first1 = EE. | last2 = Riddell | first2 = R. | last3 = Banerjee | first3 = D. | last4 = El-Zimaity | first4 = H. | last5 = Pilavdzic | first5 = D. | last6 = Dawe | first6 = P. | last7 = Magliocco | first7 = A. | last8 = Barnes | first8 = P. | last9 = Berendt | first9 = R. | title = Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee/Immunohistochemistry: best practice recommendations for standardization of immunohistochemistry tests. | journal = Am J Clin Pathol | volume = 133 | issue = 3 | pages = 354-65 | month = Mar | year = 2010 | doi = 10.1309/AJCPDYZ1XMF4HJWK | PMID = 20154273 }}</ref> | |||
==Positive== | ==Positive== | ||
*Normal breast - usually patchy staining. | |||
*[[Florid epithelial hyperplasia of the usual type]] - usually patchy staining<ref name=Ref_BP276>{{Ref BP|276}}</ref> - see ''[[Invasive_breast_cancer#Immunostains_for_typing_and_diagnosis|immunostains for typing and diagnosis of breast lesions]]''. | |||
*[[Breast carcinoma]] - most. | *[[Breast carcinoma]] - most. | ||
*[[ | **[[Ductal carcinoma in situ]] - most, usually diffuse<ref name=Ref_BP276>{{Ref BP|276}}</ref> - see ''[[Invasive_breast_cancer#Immunostains_for_typing_and_diagnosis|immunostains for typing and diagnosis of breast lesions]]''. | ||
**[[Invasive lobular carcinoma]] - all. | |||
**[[Invasive ductal carcinoma of the breast]] - most. | |||
*[[Endometrial carcinoma]]s. | |||
* PRL-producing [[pituitary adenoma]]s (Prolactioma)<ref>{{Cite journal | last1 = Delgrange | first1 = E. | last2 = Vasiljevic | first2 = A. | last3 = Wierinckx | first3 = A. | last4 = François | first4 = P. | last5 = Jouanneau | first5 = E. | last6 = Raverot | first6 = G. | last7 = Trouillas | first7 = J. | title = Expression of estrogen receptor alpha is associated with prolactin pituitary tumor prognosis and supports the sex-related difference in tumor growth. | journal = Eur J Endocrinol | volume = 172 | issue = 6 | pages = 791-801 | month = Jun | year = 2015 | doi = 10.1530/EJE-14-0990 | PMID = 25792376 }}</ref> | |||
===Occasionally positive=== | ===Occasionally positive=== | ||
Lung adenocarcinoma.<ref>{{Cite journal | last1 = | *[[Lung adenocarcinoma]] - dependent on the ER subunit target - ERα ~1%, ERβ ~79%.<ref name=pmid27069542>{{Cite journal | last1 = Tanaka | first1 = K. | last2 = Shimizu | first2 = K. | last3 = Kakegawa | first3 = S. | last4 = Ohtaki | first4 = Y. | last5 = Nagashima | first5 = T. | last6 = Kaira | first6 = K. | last7 = Horiguchi | first7 = J. | last8 = Oyama | first8 = T. | last9 = Takeyoshi | first9 = I. | title = Prognostic significance of aromatase and estrogen receptor beta expression in EGFR wild-type lung adenocarcinoma. | journal = Am J Transl Res | volume = 8 | issue = 1 | pages = 81-97 | month = | year = 2016 | doi = | PMID = 27069542 }}</ref> | ||
==Negative== | ==Negative== | ||
*[[Endocervical adenocarcinoma]].<ref name=pmid20335127>{{Cite journal | last1 = Hu | first1 = WW. | last2 = Tao | first2 = JH. | last3 = Li | first3 = GM. | last4 = Xu | first4 = X. | last5 = Yang | first5 = XM. | title = [Value of ER, VIM, CEA and p16 detection in the diagnosis and differential diagnosis of primary endocervical and endometrial adenocarcinomas]. | journal = Nan Fang Yi Ke Da Xue Xue Bao | volume = 30 | issue = 3 | pages = 526-8, 531 | month = Mar | year = 2010 | doi = | PMID = 20335127 }}</ref> | |||
==See also== | ==See also== | ||
| Line 37: | Line 45: | ||
{{Reflist|1}} | {{Reflist|1}} | ||
[[Category:Immunohistochemistry | [[Category:Immunohistochemistry]] | ||