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Difference between revisions of "KRAS mutation"
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Jensflorian (talk | contribs) (CRC update) |
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In the context of lung cancer:<ref>{{Cite journal | last1 = Riely | first1 = GJ. | last2 = Kris | first2 = MG. | last3 = Rosenbaum | first3 = D. | last4 = Marks | first4 = J. | last5 = Li | first5 = A. | last6 = Chitale | first6 = DA. | last7 = Nafa | first7 = K. | last8 = Riedel | first8 = ER. | last9 = Hsu | first9 = M. | title = Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. | journal = Clin Cancer Res | volume = 14 | issue = 18 | pages = 5731-4 | month = Sep | year = 2008 | doi = 10.1158/1078-0432.CCR-08-0646 | PMID = 18794081 }}</ref> | In the context of lung cancer:<ref>{{Cite journal | last1 = Riely | first1 = GJ. | last2 = Kris | first2 = MG. | last3 = Rosenbaum | first3 = D. | last4 = Marks | first4 = J. | last5 = Li | first5 = A. | last6 = Chitale | first6 = DA. | last7 = Nafa | first7 = K. | last8 = Riedel | first8 = ER. | last9 = Hsu | first9 = M. | title = Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. | journal = Clin Cancer Res | volume = 14 | issue = 18 | pages = 5731-4 | month = Sep | year = 2008 | doi = 10.1158/1078-0432.CCR-08-0646 | PMID = 18794081 }}</ref> | ||
* Mutations are rare in never-smokers. | * Mutations are rare in never-smokers. | ||
* KRAS G12C is the most common G > T transversion mutation in smokers.<ref>{{Cite journal | last1 = Dogan | first1 = S. | last2 = Shen | first2 = R. | last3 = Ang | first3 = DC. | last4 = Johnson | first4 = ML. | last5 = D'Angelo | first5 = SP. | last6 = Paik | first6 = PK. | last7 = Brzostowski | first7 = EB. | last8 = Riely | first8 = GJ. | last9 = Kris | first9 = MG. | title = Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. | journal = Clin Cancer Res | volume = 18 | issue = 22 | pages = 6169-77 | month = Nov | year = 2012 | doi = 10.1158/1078-0432.CCR-11-3265 | PMID = 23014527 }}</ref> | |||
* Biomarker for MEK inhibitors selumetinib and trametinib. | * Biomarker for MEK inhibitors selumetinib and trametinib. | ||