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Difference between revisions of "Endometrioid endometrial carcinoma"
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Endometrioid endometrial carcinoma (view source)
Revision as of 18:15, 24 June 2017
, 18:15, 24 June 2017→Micro: added MELF as something to look for
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===Micro=== | ===Micro=== | ||
The sections show endometrium with complex, fused and cribriform glands with scant intervening stroma over a region measuring greater than 2.1 millimetres. Focally, a desmoplastic stroma is also identified. No nuclear atypia is appreciated. | The sections show endometrium with complex, fused and cribriform glands with scant intervening stroma over a region measuring greater than 2.1 millimetres. Focally, a desmoplastic stroma is also identified. No nuclear atypia is appreciated. | ||
A subtle pattern of myoinvasion in low grade endometrial endometrioid carcinomas, microcystic, elongated and fragmented (MELF) should be searched for in the absence of frank invasion. At low power, microcystic tumor glands lie separated by muscle from non-invasive carcinoma in edematous stroma. At higher power lie microcystic glands with neutrophils, as well as elongated glands lined by flattened tumor cells. Eosinophilic tumor cells or squamous cells can often be seen within the lumens. <ref name=pmid14501811>{{cite journal |author= Murray SK, Young RH, Scully RE |title= Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinoma: a study of their frequency, associated diagnostic problems, and prognostic significance |journal= Int J Gynecol Pathol |volume=22 |issue= |pages=324-333 |year=2003 | pmid=14501811 |doi=10.1097/01.pgp.0000092161.33490.a9 }}</ref> | |||
====Endocervical versus endometrial - biopsy==== | ====Endocervical versus endometrial - biopsy==== | ||