Difference between revisions of "Dermatopathology"

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*[[Dermatitis herpetiformis]]: gluten enteropathy ([[celiac disease]]), [[thyroid]] disease, intestinal [[lymphoma]].<ref name=Ref_TN2007_D23>{{Ref TN2007|D23}}</ref>
*[[Dermatitis herpetiformis]]: gluten enteropathy ([[celiac disease]]), [[thyroid]] disease, intestinal [[lymphoma]].<ref name=Ref_TN2007_D23>{{Ref TN2007|D23}}</ref>
*[[Pemphigus vulgaris]]: [[thymoma]], myasthenia gravis, malignancy.<ref name=Ref_TN2007_D23>{{Ref TN2007|D23}}</ref>
*[[Pemphigus vulgaris]]: [[thymoma]], myasthenia gravis, malignancy.<ref name=Ref_TN2007_D23>{{Ref TN2007|D23}}</ref>
<br>
 
[[File:3767 dp sl 1.png |Lipoid proteinosis]]
===Lipoid proteinosis===
[[File:3767 dp sl 2.png |Lipoid proteinosis]]<br>
<gallery>
Lipoid proteinosis. A. Inner labial biopsy shows subepithelial hyalinized pink/red material, about blood vessels and in general.  B. The particularly glassy appearance of the material in areas is evident at high power.
File:3767 dp sl 1.png |Lipoid proteinosis (A)
<br>
File:3767 dp sl 2.png |Lipoid proteinosis (B)
[[File:DP16MR17 sl 1.png| Xanthogranuloma in scrotal skin.]]
</gallery>
[[File:DP16MR17 sl 2.png| Xanthogranuloma in scrotal skin.]]
A. Inner labial biopsy shows subepithelial hyalinized pink/red material, about blood vessels and in general.  B. The particularly glassy appearance of the material in areas is evident at high power.
[[File:DP16MR17 sl 3.png| Xanthogranuloma in scrotal skin.]]
 
[[File:DP16MR17 sl 4.png| Xanthogranuloma in scrotal skin.]]
===Xanthogranuloma in scrotal skin.===
<br>
<gallery>
Xanthogranuloma in scrotal skin.  A. Pseudoepitheliomatous hyperplasia seemingly forms a dermal mass. B. Parakeratosis tops epidermis. C. Neutrophils lie in the center of the apparent mass. D. Diagnostic xanthoma cells lie in dermal papillae.
File:DP16MR17 sl 1.png| Xanthogranuloma in scrotal skin. (A)
<br>
File:DP16MR17 sl 2.png| Xanthogranuloma in scrotal skin. (B)
[[File:DP13AP17 sl1.png| Silicone granuloma]]
File:DP16MR17 sl 3.png| Xanthogranuloma in scrotal skin. (C)
[[File:DP13AP17 sl2.png| Silicone granuloma]]
File:DP16MR17 sl 4.png| Xanthogranuloma in scrotal skin. (D)
[[File:DP13AP17 sl3.png| Silicone granuloma]]
</gallery>
[[File:DP13AP17 sl4.png| Silicone granuloma]]
A. Pseudoepitheliomatous hyperplasia seemingly forms a dermal mass. B. Parakeratosis tops epidermis. C. Neutrophils lie in the center of the apparent mass. D. Diagnostic xanthoma cells lie in dermal papillae.
<br>
 
Silicone granuloma. A. The dermis resembles Swiss cheese. B. Macrophages, some with more than one nucleus, accompany empty ovoid spaces. C. Some macrophages resemble Teuton body giant cells. D. An admixture of lymphocytes is not at all unusual.
===Silicone granuloma===
[[File:DP20AP17 sl 1.png| Dermal histoplasmosis]]
<gallery>
[[File:DP20AP17 sl 2.png| Dermal histoplasmosis]]
File:DP13AP17 sl1.png| Silicone granuloma (A)
[[File:DP20AP17 sl 3.png| Dermal histoplasmosis]]
File:DP13AP17 sl2.png| Silicone granuloma (B)
[[File:DP20AP17 sl 4.png| Dermal histoplasmosis]]<br>
File:DP13AP17 sl3.png| Silicone granuloma (C)
Histoplasmosis in skin. A. Extending from papillary dermis into dermis is a chronic, blue inflammatory infiltrate. B. The infiltrate comprises lymphocytes, plasma cells, and macrophages. C. At the edge of the biopsy pink strews inflammatory cells; this pink invasion of inflammation, so to speak, is a good place to look for organisms.  D. High power reveals sometimes budding yeast forms in clear spaces.
File:DP13AP17 sl4.png| Silicone granuloma (D)
</gallery>
A. The dermis resembles Swiss cheese. B. Macrophages, some with more than one nucleus, accompany empty ovoid spaces. C. Some macrophages resemble Teuton body giant cells. D. An admixture of lymphocytes is not at all unusual.
 
====Histoplasmosis in skin====
<gallery>
File:DP20AP17 sl 1.png| Dermal histoplasmosis (A)
File:DP20AP17 sl 2.png| Dermal histoplasmosis (B)
File:DP20AP17 sl 3.png| Dermal histoplasmosis (C)
File:DP20AP17 sl 4.png| Dermal histoplasmosis (D)
</gallery>
A. Extending from papillary dermis into dermis is a chronic, blue inflammatory infiltrate. B. The infiltrate comprises lymphocytes, plasma cells, and macrophages. C. At the edge of the biopsy pink strews inflammatory cells; this pink invasion of inflammation, so to speak, is a good place to look for organisms.  D. High power reveals sometimes budding yeast forms in clear spaces.


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