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Endocervical adenocarcinoma in situ (view source)
Revision as of 18:38, 14 February 2017
, 18:38, 14 February 2017→Microscopic: Put in ioffe scoring system
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#*Normal gland spacing - lack of complexity ("lobular pattern"). | #*Normal gland spacing - lack of complexity ("lobular pattern"). | ||
#*Normal gland depth (subjective). | #*Normal gland depth (subjective). | ||
Ioffe, et al, :<ref name=pmid12657929>{{cite journal |author=Ioffe OB, Sagae S, Moritani S, Dahmoush L, Chen TT, Silverberg SG. |title=Proposal of a new scoring scheme for the diagnosis of noninvasive endocervical glandular lesions |journal=Am J Surg Pathol | volume=27 | issue=4| pages=452–460 | year=2003 | pmid=12657929 |pmc= |doi= |url= }}</ref> devised a reproducible schema by which one might discern reactive glandular atypia, glandular dysplasia, and adenocarcinoma in situ, summarized in the table below from the article: | |||
Sum the scores for stratification, nuclear atypia, and mitoses/apoptotic bodies<br> | |||
<br> | |||
Stratification<br> | |||
None (0 points)<br> | |||
Mild (1 point)<br> | |||
Moderate (2 points)<br> | |||
Up to the luminal surface (3 points)<br> | |||
<br> | |||
Nuclear atypia<br> | |||
As normal (0 points)<br> | |||
Small (size of normal) or slightly enlarged uniform nuclei, minimal hyperchromasia, little dispolarity, no nucleoli (1 point)<br> | |||
Nuclear enlargement (≤3× normal), moderate anisocytosis/hyperchromasia/dispolarity, occasional small nucleoli (2 points)<br> | |||
Large nuclei (>3× normal), marked anisocytosis, marked hyperchromasia, severe dispolarity, frequent prominent nucleoli (3 points)<br> | |||
<br> | |||
Mitoses and apoptoses in two most active glands, number per gland (average between two glands)<br> | |||
None (0 points)<br> | |||
Less than 0.5 per gland (1 point)<br> | |||
0.6–3.0 per gland (2 points)<br> | |||
>3.0 per gland (3 points)<br> | |||
<br> | |||
Total score 0–3 = benign 4–5 = endocervical glandular dysplasia (EGD) 6–9 = adenocarcinoma in situ | |||
DDx: | DDx: | ||