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Difference between revisions of "Liver metastasis"
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→Micro: add a met RCC
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(→Micro: add a met RCC) |
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====Micro==== | ====Micro==== | ||
The section show liver parenchyma with an invasive adenocarcinoma. The adenocarcinoma | |||
has well formed glands with dirty necrosis. The nuclei are appear crowded and | |||
have an ellipsoid shape. Focally, zones of necrosis are present. See background liver. | |||
BACKGROUND LIVER (BASED ON H&E ONLY)<br> | |||
Fibrosis: not identified.<br> | |||
Fibrous septa: absent.<br> | |||
Septa with curved contours: absent.<br> | |||
Large droplet steatosis (% of hepatocytes): mild (20%).<br> | |||
Ballooning of hepatocytes: not identified.<br> | |||
Mallory-Denk bodies: not identified.<br> | |||
Portal inflammation: present, mild.<br> | |||
Interface activity: not identified.<br> | |||
Lobular necroinflammation: not identified.<br> | |||
Ducts: present in normal numbers.<br> | |||
Duct injury: not identified.<br> | |||
Ductular reaction: not identified.<br> | |||
Cholestasis: present peritumoural, otherwise absent.<br> | |||
Terminal hepatic venules: present.<br> | |||
Ground glass cells with routine stains: not identified. | |||
{| | {| | ||
[[File:1 Met scc 1 680x512px.tif|Metastatic poorly differentiated neuroendocrine carcinoma of pulmonary origin.]] | [[File:1 Met scc 1 680x512px.tif|Metastatic poorly differentiated neuroendocrine carcinoma of pulmonary origin.]] | ||
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Metastatic thyroid carcinoma. A. Carcinoma with open spaces spares part of a normal liver lobule [arrow] (40X). B. A sheet with acini [arrows] would indicate only adenocarcinoma (400X). C. A true papilla with vascular spaces [arrows] suggests papillary carcinoma (400X). D. Some spaces show tumor nuclei with inclusions [arrows] (400X). E. Tumor nuclei are TTF1 positive, which can also be seen with lung cancer (IHC 400X). F. Specific thyroglobulin positivity rendered the specific diagnosis known (IHC 400X). | Metastatic thyroid carcinoma. A. Carcinoma with open spaces spares part of a normal liver lobule [arrow] (40X). B. A sheet with acini [arrows] would indicate only adenocarcinoma (400X). C. A true papilla with vascular spaces [arrows] suggests papillary carcinoma (400X). D. Some spaces show tumor nuclei with inclusions [arrows] (400X). E. Tumor nuclei are TTF1 positive, which can also be seen with lung cancer (IHC 400X). F. Specific thyroglobulin positivity rendered the specific diagnosis known (IHC 400X). | ||
[[File: RCC MET 1 sl 1.png| Metastasis of renal cell carcinoma to liver]] | |||
[[File: RCC MET 1 sl 2.png| Metastasis of renal cell carcinoma to liver]] | |||
[[File: RCC MET 1 sl 3.png| Metastasis of renal cell carcinoma to liver]] | |||
[[File: RCC MET 1 sl 4.png| Metastasis of renal cell carcinoma to liver]] | |||
[[File: RCC MET 1 sl 5.png| Metastasis of renal cell carcinoma to liver]] | |||
Metastasis of renal cell carcinoma to liver. A. Upper core shows blue necrosis; remainder shows replacement by tumor. B. In part cytoplasm is abundant and amphophilic, suggesting hepatocellular carcinoma. C. In part, tumor shows clear cytoplasm, raising alternative explanations. D. High power of clear area shows finely reticulated cytoplasm with sharp intercellular borders. Nuclei are bizarrely shaped, often with nucleoli. Arrow shows an aberrant mitosis. E. Immunostain for RCC proves renal cell carcinoma. | |||
===Melanoma=== | ===Melanoma=== | ||