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Difference between revisions of "Traditional adenoma"
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| Micro = nuclear changes - esp. at the surface (hyperchromatic elongated nuclei or round cleared nuclei), nuclear crowding/pseudostratification, +/- loss of nuclear polarity, loss/decrease of goblet cells, cytoplasmic hyperchromasia | | Micro = nuclear changes - esp. at the surface (hyperchromatic elongated nuclei or round cleared nuclei), nuclear crowding/pseudostratification, +/- loss of nuclear polarity, loss/decrease of goblet cells, cytoplasmic hyperchromasia | ||
| Subtypes = [[tubular adenoma]], [[villous adenoma]], [[tubulovillous adenoma]] | | Subtypes = [[tubular adenoma]], [[villous adenoma]], [[tubulovillous adenoma]] | ||
| LMDDx = [[sessile serrated adenoma]] with dysplasia, [[gastrointestinal polyps]] | | LMDDx = [[sessile serrated adenoma]] with dysplasia, reactive changes in other [[gastrointestinal polyps]], invasive adenocarcinoma, adenoma-like adenocarcinoma | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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***The base is more mature (more globlet cells, no nuclear changes -- less blue). | ***The base is more mature (more globlet cells, no nuclear changes -- less blue). | ||
*[[Ampullary adenoma]]s often have less prominent pseudostratification and fine chromatin. | *[[Ampullary adenoma]]s often have less prominent pseudostratification and fine chromatin. | ||
DDx: | |||
*Reactive changes due to inflammation. | |||
*Invasive adenocarcinoma. | |||
**Adenoma-like adenocarcinoma.<ref name=pmid25913616>{{Cite journal | last1 = Gonzalez | first1 = RS. | last2 = Cates | first2 = JM. | last3 = Washington | first3 = MK. | last4 = Beauchamp | first4 = RD. | last5 = Coffey | first5 = RJ. | last6 = Shi | first6 = C. | title = Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation. | journal = Histopathology | volume = 68 | issue = 2 | pages = 183-90 | month = Jan | year = 2016 | doi = 10.1111/his.12725 | PMID = 25913616 }}</ref> | |||
===Images=== | ===Images=== | ||
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<pre> | <pre> | ||
POLYP, TRANSVERSE COLON, BIOPSY: | POLYP, TRANSVERSE COLON, BIOPSY: | ||
- TUBULAR ADENOMA WITH FOCAL HIGH-GRADE DYSPLASIA. | - TUBULAR ADENOMA WITH FOCAL HIGH-GRADE DYSPLASIA, MARGINS CLEAR, SEE COMMENT. | ||
COMMENT: | |||
The case was partially reviewed internally by Dr. Pathology and there is agreement high-grade dysplasia is focally present. | |||
</pre> | </pre> | ||
Note: | |||
*"Focal" is something that should prompt review; the management decision often turns on high grade versus low grade. | |||
===Tubular adenoma with high-grade dysplasia=== | ===Tubular adenoma with high-grade dysplasia=== | ||
<pre> | <pre> | ||
POLYP, SIGMOID COLON, BIOPSY: | POLYP, SIGMOID COLON, BIOPSY: | ||
- TUBULAR ADENOMA WITH HIGH-GRADE DYSPLASIA. | - TUBULAR ADENOMA WITH HIGH-GRADE DYSPLASIA, MARGINS CLEAR. | ||
</pre> | </pre> | ||