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Difference between revisions of "Pleomorphic lipoma"
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'''Pleomorphic_lipoma''' is a rare [[Adipocytic tumours|adipocytic tumour]]. | |||
==General== | |||
*Rare. | |||
*May mimic a malignancy.<ref name=pmid15510605>{{Cite journal | last1 = Persichetti | first1 = P. | last2 = Di Lella | first2 = F. | last3 = Marangi | first3 = GF. | last4 = Cagli | first4 = B. | last5 = Simone | first5 = P. | last6 = Tenna | first6 = S. | last7 = Rabitri | first7 = C. | last8 = Cassandro | first8 = R. | last9 = Esposito | first9 = V. | title = Pleomorphic lipoma: a definite histopathological entity. | journal = Anticancer Res | volume = 24 | issue = 5B | pages = 3157-9 | month = | year = | doi = | PMID = 15510605 }}</ref> | |||
*Male > female.<ref name=pmid18181679>{{Cite journal | last1 = Syed | first1 = S. | last2 = Martin | first2 = AM. | last3 = Haupt | first3 = H. | last4 = Podolski | first4 = V. | last5 = Brooks | first5 = JJ. | title = Frequent detection of androgen receptors in spindle cell lipomas: an explanation for this lesion's male predominance? | journal = Arch Pathol Lab Med | volume = 132 | issue = 1 | pages = 81-3 | month = Jan | year = 2008 | doi = 10.1043/1543-2165(2008)132[81:FDOARI]2.0.CO;2 | PMID = 18181679 }}</ref> | |||
==Gross== | |||
*Classically shoulder and neck region in adults.<ref>URL: [http://www.webpathology.com/image.asp?n=2&Case=435 http://www.webpathology.com/image.asp?n=2&Case=435]. Accessed on: 3 October 2011.</ref> | |||
DDx - shoulder lesions: | |||
*[[Elastofibroma]]. | |||
*[[Desmoplastic fibroblastoma]]. | |||
==Microscopic== | |||
Features: | |||
*Multinucleated cells - "floret cells" - '''key feature'''. | |||
**Solid eosinophilic cytoplasm. | |||
**Peripheral nuclei - impart a knobby border to the cells. | |||
*Fibrous septa. | |||
Notes: | |||
*May overlap with ''[[spindle cell lipoma]]''.<ref name=spc_stanford>URL: [http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/ http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/]. Accessed on: 4 December 2010.</ref> | |||
*Floret cell - may look similar to [[Touton giant cell]]s. | |||
Images: | |||
*[http://www.webpathology.com/image.asp?case=435&n=1 Pleomorphic lipoma - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=2&Case=435 Pleomorphic lipoma - high mag. (webpathology.com)]. | |||
DDx: | |||
*[[Liposarcoma]].<ref name=pmid6884998>{{Cite journal | last1 = Azzopardi | first1 = JG. | last2 = Iocco | first2 = J. | last3 = Salm | first3 = R. | title = Pleomorphic lipoma: a tumour simulating liposarcoma. | journal = Histopathology | volume = 7 | issue = 4 | pages = 511-23 | month = Jul | year = 1983 | doi = | PMID = 6884998 }}</ref> | |||
*Ancient [[neurofibroma]]. | |||
*Ancient [[schwannoma]]. | |||
==IHC== | |||
*AR +ve - ~95% in men, ~85% in women.<ref name=pmid18181679>{{Cite journal | last1 = Syed | first1 = S. | last2 = Martin | first2 = AM. | last3 = Haupt | first3 = H. | last4 = Podolski | first4 = V. | last5 = Brooks | first5 = JJ. | title = Frequent detection of androgen receptors in spindle cell lipomas: an explanation for this lesion's male predominance? | journal = Arch Pathol Lab Med | volume = 132 | issue = 1 | pages = 81-3 | month = Jan | year = 2008 | doi = 10.1043/1543-2165(2008)132[81:FDOARI]2.0.CO;2 | PMID = 18181679 }}</ref> | |||
*CD34 +ve (26 +ve of 26 cases<ref name=pmid25219904>{{Cite journal | last1 = Cheah | first1 = A. | last2 = Billings | first2 = S. | last3 = Goldblum | first3 = J. | last4 = Hornick | first4 = J. | last5 = Uddin | first5 = N. | last6 = Rubin | first6 = B. | title = Spindle cell/pleomorphic lipomas of the face: an under-recognized diagnosis. | journal = Histopathology | volume = 66 | issue = 3 | pages = 430-7 | month = Feb | year = 2015 | doi = 10.1111/his.12548 | PMID = 25219904 }}</ref>). | |||
*Desmin -ve (0 +ve of 20 cases<ref name=pmid25219904/>). | |||
*ER -ve/+ve (5 +ve of 21 cases<ref name=pmid25219904/>). | |||
==See also== | |||
*[[Adipocytic tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Adipocytic tumours]] | |||