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| ==Fontana-Masson stain== | | ==Fontana-Masson stain== |
| *[[AKA]] ''Masson-Fontana stain'',<ref name=pmid16081962>{{Cite journal | last1 = Gaitanis | first1 = G. | last2 = Chasapi | first2 = V. | last3 = Velegraki | first3 = A. | title = Novel application of the masson-fontana stain for demonstrating Malassezia species melanin-like pigment production in vitro and in clinical specimens. | journal = J Clin Microbiol | volume = 43 | issue = 8 | pages = 4147-51 | month = Aug | year = 2005 | doi = 10.1128/JCM.43.8.4147-4151.2005 | PMID = 16081962 }}</ref> ''Fontana-Masson stain for melanin'', ''melanin stain''. | | *[[AKA]] ''Masson-Fontana stain'',<ref name=pmid16081962>{{Cite journal | last1 = Gaitanis | first1 = G. | last2 = Chasapi | first2 = V. | last3 = Velegraki | first3 = A. | title = Novel application of the masson-fontana stain for demonstrating Malassezia species melanin-like pigment production in vitro and in clinical specimens. | journal = J Clin Microbiol | volume = 43 | issue = 8 | pages = 4147-51 | month = Aug | year = 2005 | doi = 10.1128/JCM.43.8.4147-4151.2005 | PMID = 16081962 }}</ref> ''Fontana-Masson stain for melanin'', ''melanin stain''. |
| *A type of silver stain.
| | {{Main|Fontana-Masson stain}} |
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| Stains:
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| #Melanin.
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| #"Argentaffin granules" of the digestive tract.
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| #Pigment deposition due to minocycline treatment.<ref name=pmid15605966>{{Cite journal | last1 = Patterson | first1 = JW. | last2 = Wilson | first2 = B. | last3 = Wick | first3 = MR. | last4 = Heath | first4 = C. | title = Hyperpigmented scar due to minocycline therapy. | journal = Cutis | volume = 74 | issue = 5 | pages = 293-8 | month = Nov | year = 2004 | doi = | PMID = 15605966 }}</ref>
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| ===Use===
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| *Stain for melanin.
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| **Displays melanin - whether it be in melanocytes, keratinocytes or melanophages.
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| **IHC stains, i.e. ''Melan A, SOX10 or MITF'' are preferable for displaying ''melanocytes''.
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| **Used to differentiate brown pigments (lipofuscin, hemosiderin, melanin).<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref>
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| **Used to document Minocycline type II drug induced pigment deposition
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| ***Minocycline pigment, Type II will stain with both the Fontana-Masson stain AND the Perls iron stain.<ref name=pmid19595269>{{cite journal |author=Geria AN, Tajirian AL, Kihiczak G, Schwartz RA |title=Minocycline-induced skin pigmentation: an update |journal=Acta Dermatovenerol Croat |volume=17 |issue=2 |pages=123–6 |year=2009 |pmid=19595269 |doi= |url=}}</ref>
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| **Used in the differential diagnosis of hypomelanosis
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| ***Idiopathic hypomelanosis will demonstrate ONLY loss of melanin with the Fontana-Masson stain - melanocytes will not be absent with the Melan A stain.
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| ***Vitiligo will show loss of melanin AND loss of melanocytes with a Melan A stain.
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| Image:
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| *[http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm Fontana-Masson stain (vetmed.vt.edu)].
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| ==Schmorl's stain== | | ==Schmorl's stain== |