Difference between revisions of "Colorectal adenocarcinoma"

Colorectal adenocarcinoma (view source)

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-* † Greenson ''et al.'' says ''>2 lymphocytes/HPF, where 5 HPF are sampled''. Since the sample area given by Greenson ''et al.'' is 0.94 mm<sup>2</sup>, their field diameter is ~ 0.489 mm and corresponds to ~ 20 mm eye piece.
+* † Greenson ''et al.'' says ''>2 lymphocytes/HPF, where 5 HPF are sampled''. Since the sample area given by Greenson ''et al.'' is 0.94 mm<sup>2</sup>, their field diameter is ~ 0.4892 mm. This field diameter corresponds to a 20 mm eye piece (0.4892 mm * 40x = 19.57 mm).
 **Many microscopes in use today have a field diameter at 40x of ~ 0.55 mm; thus, 4 fields would be approximately 0.95 mm<sup>2</sup>.
 * †† Definitions vary substantially - some authors consider lymphocytes adjacent to the tumour (in the stroma around the tumour cells) "intratumoural".<reF name=pmid9349235>{{Cite journal  | last1 = Ropponen | first1 = KM. | last2 = Eskelinen | first2 = MJ. | last3 = Lipponen | first3 = PK. | last4 = Alhava | first4 = E. | last5 = Kosma | first5 = VM. | title = Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. | journal = J Pathol | volume = 182 | issue = 3 | pages = 318-24 | month = Jul | year = 1997 | doi = 10.1002/(SICI)1096-9896(199707)182:3318::AID-PATH8623.0.CO;2-6 | PMID = 9349235 |URL = http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291096-9896%28199707%29182:3%3C318::AID-PATH862%3E3.0.CO;2-6/pdf}}</ref>