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Difference between revisions of "Colorectal adenocarcinoma"
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Colorectal adenocarcinoma (view source)
Revision as of 14:33, 16 December 2015
, 14:33, 16 December 2015→Microscopic
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====Microscopic==== | ====Microscopic==== | ||
Features: | Features: | ||
*Lymphocytes | *>10 lymphocytes/0.94 mm<sup>2</sup>.<ref name=pmid12717242>{{Cite journal | last1 = Greenson | first1 = JK. | last2 = Bonner | first2 = JD. | last3 = Ben-Yzhak | first3 = O. | last4 = Cohen | first4 = HI. | last5 = Miselevich | first5 = I. | last6 = Resnick | first6 = MB. | last7 = Trougouboff | first7 = P. | last8 = Tomsho | first8 = LD. | last9 = Kim | first9 = E. | title = Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability. | journal = Am J Surg Pathol | volume = 27 | issue = 5 | pages = 563-70 | month = May | year = 2003 | doi = | PMID = 12717242 }}</ref> † | ||
**Other lymphocytes do not count. | **Lymphocytes should be between the tumour cells.<ref name=pmid12717242/><ref name=pmid19638537/> †† | ||
***Other lymphocytes do not count. | |||
Note: | Note: | ||
* † Definitions vary substantially - some authors consider lymphocytes adjacent to the tumour (in the stroma around the tumour cells) "intratumoural".<reF name=pmid9349235>{{Cite journal | last1 = Ropponen | first1 = KM. | last2 = Eskelinen | first2 = MJ. | last3 = Lipponen | first3 = PK. | last4 = Alhava | first4 = E. | last5 = Kosma | first5 = VM. | title = Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. | journal = J Pathol | volume = 182 | issue = 3 | pages = 318-24 | month = Jul | year = 1997 | doi = 10.1002/(SICI)1096-9896(199707)182:3318::AID-PATH8623.0.CO;2-6 | PMID = 9349235 |URL = http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291096-9896%28199707%29182:3%3C318::AID-PATH862%3E3.0.CO;2-6/pdf}}</ref> | * † Greenson ''et al.'' says ''>2 lymphocytes/HPF, where 5 HPF are sampled''. Since the sample area given by Greenson ''et al.'' is 0.94 mm<sup>2</sup>, their field diameter is ~ 0.489 mm and corresponds to ~ 20 mm eye piece. | ||
**Many microscopes in use today have a field diameter at 40x of ~ 0.55 mm; thus, 4 fields would be approximately 0.95 mm<sup>2</sup>. | |||
* †† Definitions vary substantially - some authors consider lymphocytes adjacent to the tumour (in the stroma around the tumour cells) "intratumoural".<reF name=pmid9349235>{{Cite journal | last1 = Ropponen | first1 = KM. | last2 = Eskelinen | first2 = MJ. | last3 = Lipponen | first3 = PK. | last4 = Alhava | first4 = E. | last5 = Kosma | first5 = VM. | title = Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. | journal = J Pathol | volume = 182 | issue = 3 | pages = 318-24 | month = Jul | year = 1997 | doi = 10.1002/(SICI)1096-9896(199707)182:3318::AID-PATH8623.0.CO;2-6 | PMID = 9349235 |URL = http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291096-9896%28199707%29182:3%3C318::AID-PATH862%3E3.0.CO;2-6/pdf}}</ref> | |||
=====Images===== | =====Images===== | ||