Account-creators
1,040
edits
Difference between revisions of "Neuropathology tumours"
Jump to navigation
Jump to search
→Neuronal and mixed neuronal/glial tumours: liponeurocytoma + images
Jensflorian (talk | contribs) (little sorting) |
Jensflorian (talk | contribs) (→Neuronal and mixed neuronal/glial tumours: liponeurocytoma + images) |
||
| Line 314: | Line 314: | ||
* Dysplastic ganglioglioma of the cerebellum (Lhermitte-Duclos) | * Dysplastic ganglioglioma of the cerebellum (Lhermitte-Duclos) | ||
* [[Paraganglioma]] | * [[Paraganglioma]] | ||
===Cerebellar liponeurocytoma=== | |||
* Previously called ''lipomatous medulloblastoma'' (name changed in WHO 2000). | |||
* Mean age: 50 years. | |||
* As the name states: A tumour of the cerebellum. | |||
** But cases outside cerebellum reported that would qualify.<ref>{{Cite journal | last1 = Gupta | first1 = K. | last2 = Salunke | first2 = P. | last3 = Kalra | first3 = I. | last4 = Vasishta | first4 = RK. | title = Central liponeurocytoma: case report and review of literature. | journal = Clin Neuropathol | volume = 30 | issue = 2 | pages = 80-5 | month = | year = | doi = | PMID = 21329617 }}</ref> | |||
* WHO grade II <ref>{{Cite journal | last1 = Nishimoto | first1 = T. | last2 = Kaya | first2 = B. | title = Cerebellar liponeurocytoma. | journal = Arch Pathol Lab Med | volume = 136 | issue = 8 | pages = 965-9 | month = Aug | year = 2012 | doi = 10.5858/arpa.2011-0337-RS | PMID = 22849747 }}</ref> (upgraded from WHO grade I in 2007)<ref>{{Cite journal | last1 = Brat | first1 = DJ. | last2 = Parisi | first2 = JE. | last3 = Kleinschmidt-DeMasters | first3 = BK. | last4 = Yachnis | first4 = AT. | last5 = Montine | first5 = TJ. | last6 = Boyer | first6 = PJ. | last7 = Powell | first7 = SZ. | last8 = Prayson | first8 = RA. | last9 = McLendon | first9 = RE. | title = Surgical neuropathology update: a review of changes introduced by the WHO classification of tumours of the central nervous system, 4th edition. | journal = Arch Pathol Lab Med | volume = 132 | issue = 6 | pages = 993-1007 | month = Jun | year = 2008 | doi = 10.1043/1543-2165(2008)132[993:SNUARO]2.0.CO;2 | PMID = 18517285 }}</ref> | |||
*ICD-O code: 9506/1 | |||
====Histo==== | |||
* Advanced neuronal and lipomatous differentiation. | |||
* Neurocytes: round to oval nuclei with clear cytoplasm. | |||
* Quite cellular. | |||
* Mitoses almost absent. | |||
====IHC==== | |||
* [[GFAP]] +/-ve (focal). | |||
* [[MAP2]] +ve. | |||
* Synaptophysin +ve. | |||
* NeuN +ve. | |||
* MIB-1: usu 1-3%. | |||
<gallery> | |||
File:Cerebellar liponeurocytoma.jpg | Liponeurocytoma, HE (WC/Marvin101). | |||
File:Liponeurocytoma Synaptophysin.jpg | Liponeurocytoma, Synapto (WC/Marvin101). | |||
File:Cerebellar Liponeurocytoma HE.jpg | Liponeurocytoma, HE (WC/jensflorian). | |||
File:Cerebellar Liponeurocytoma Synaptophysin.jpg | Liponeurocytoma, Synapto (WC/jensflorian). | |||
</gallery> | |||
====DDx==== | |||
* [[Medulloblastoma]] | |||
* [[Neurocytoma]] | |||
===Gangliocytoma=== | ===Gangliocytoma=== | ||