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Difference between revisions of "Renal cell carcinoma with sarcomatoid differentiation"
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Renal cell carcinoma with sarcomatoid differentiation (view source)
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'''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial derived [[kidney tumour]] with malignant mesenchymal differentiation. | '''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial derived [[kidney tumour]] with malignant mesenchymal differentiation. | ||
These tumours are '''not''' recognized as a distinct type of renal cell carcinoma; they are classified by the non-sarcomatous component. If a renal tumour is purely sarcomatous it is ''[[renal cell carcinoma, unclassified]]''. | These tumours are '''not''' recognized as a distinct type of renal cell carcinoma;<ref name=pmid22234634>{{Cite journal | last1 = Shuch | first1 = B. | last2 = Bratslavsky | first2 = G. | last3 = Linehan | first3 = WM. | last4 = Srinivasan | first4 = R. | title = Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies. | journal = Oncologist | volume = 17 | issue = 1 | pages = 46-54 | month = | year = 2012 | doi = 10.1634/theoncologist.2011-0227 | PMID = 22234634 }}</ref> they are classified by the non-sarcomatous component. If a renal tumour is purely sarcomatous it is ''[[renal cell carcinoma, unclassified]]''. | ||
'''Sarcomatoid renal cell carcinoma''', abbreviated '''sarcomatoid RCC''', redirects here. | '''Sarcomatoid renal cell carcinoma''', abbreviated '''sarcomatoid RCC''', redirects here. | ||
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*Not recognized as a distinct entity in 2004 WHO classification.<ref name=pmid16442207>{{Cite journal | last1 = Lopez-Beltran | first1 = A. | last2 = Scarpelli | first2 = M. | last3 = Montironi | first3 = R. | last4 = Kirkali | first4 = Z. | title = 2004 WHO classification of the renal tumors of the adults. | journal = Eur Urol | volume = 49 | issue = 5 | pages = 798-805 | month = May | year = 2006 | doi = 10.1016/j.eururo.2005.11.035 | PMID = 16442207 }}</ref> | *Not recognized as a distinct entity in 2004 WHO classification.<ref name=pmid16442207>{{Cite journal | last1 = Lopez-Beltran | first1 = A. | last2 = Scarpelli | first2 = M. | last3 = Montironi | first3 = R. | last4 = Kirkali | first4 = Z. | title = 2004 WHO classification of the renal tumors of the adults. | journal = Eur Urol | volume = 49 | issue = 5 | pages = 798-805 | month = May | year = 2006 | doi = 10.1016/j.eururo.2005.11.035 | PMID = 16442207 }}</ref> | ||
**It is considered an indicator of progression. | **It is considered an indicator of progression. | ||
**Previously considered a distinct entity.<ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal | last1 = Cangiano | first1 = T. | last2 = Liao | first2 = J. | last3 = Naitoh | first3 = J. | last4 = Dorey | first4 = F. | last5 = Figlin | first5 = R. | last6 = Belldegrun | first6 = A. | title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. | journal = J Clin Oncol | volume = 17 | issue = 2 | pages = 523-8 | month = Feb | year = 1999 | doi = | PMID = 10080595 | URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref> | **Previously considered a distinct entity.<ref name=pmid22234634/><ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal | last1 = Cangiano | first1 = T. | last2 = Liao | first2 = J. | last3 = Naitoh | first3 = J. | last4 = Dorey | first4 = F. | last5 = Figlin | first5 = R. | last6 = Belldegrun | first6 = A. | title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. | journal = J Clin Oncol | volume = 17 | issue = 2 | pages = 523-8 | month = Feb | year = 1999 | doi = | PMID = 10080595 | URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref> | ||
*Tend to present at higher stage. | *Tend to present at higher stage. | ||
*Worse prognosis when adjusted for [[cancer staging|stage]]. | *Worse prognosis when adjusted for [[cancer staging|stage]]. | ||