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Cytomegalovirus colitis (view source)
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'''Cytomegalovirus colitis''' is a type of [[colitis]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = CMV colitis - high mag - cropped.jpg | |||
| Width = | |||
| Caption = CMV colitis. [[H&E stain]]. (WC) | |||
| Synonyms = | |||
| Micro = enlarged nucleus - classically in endothelial cells, +/-cytoplasmic inclusions | |||
| Subtypes = | |||
| LMDDx = [[infectious colitis]] | |||
| Stains = | |||
| IHC = CMV +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[colon]] | |||
| Assdx = +/-[[HIV]] infection | |||
| Syndromes = | |||
| Clinicalhx = +/-immunosuppression, +/-immune incompetent (e.g. transplant recipients) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Cytomegalovirus colitis''' is a type of [[colitis]] caused by [[cytomegalovirus]]. | |||
==General== | ==General== | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Enlarged nucleus - | *Enlarged nucleus - typically in endothelial cells. | ||
**Nucleus classically has peripheral clearing - described as "owl's eye". | |||
**Epithelial cells and lamina propria cells may also be affected.<ref>URL: [http://www.annalsgastro.gr/index.php/annalsgastro/article/view/579 http://www.annalsgastro.gr/index.php/annalsgastro/article/view/579]. Accessed on: 8 February 2016.</ref> | |||
DDx: | DDx: | ||
| Line 17: | Line 51: | ||
<gallery> | <gallery> | ||
Image:CMV_colitis_-_intermed_mag.jpg | CMV colitis - intermed. mag. (WC/Nephron) | Image:CMV_colitis_-_intermed_mag.jpg | CMV colitis - intermed. mag. (WC/Nephron) | ||
Image:CMV_colitis_- | Image:CMV_colitis_-_high_mag.jpg | CMV colitis - high mag. (WC/Nephron) | ||
Image:CMV colitis vessel high mag.jpg | CMV nuclear inclusions in submucosal vessel - high mag. (WC/MO) | |||
Image:CMV colitis submucosa high mag.jpg | CMV nuclear inclusions in submucosa of colon - high mag. (WC/MO) | |||
</gallery> | </gallery> | ||
www: | www: | ||
*[http://www.flickr.com/photos/lunarcaustic/4615988256/ CMV colitis (flickr.com/lunar caustic)]. | *[http://www.flickr.com/photos/lunarcaustic/4615988256/ CMV colitis (flickr.com/lunar caustic)]. | ||
*[http://www.flickr.com/photos/lunarcaustic/4615988164/ CMV colitis (flickr.com/lunar caustic)] | *[http://www.flickr.com/photos/lunarcaustic/4615988164/ CMV colitis (flickr.com/lunar caustic)] | ||
*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=000500 CMV colitis (unibas.ch)]. | |||
==IHC== | ==IHC== | ||
*CMV +ve. | *CMV +ve. | ||
**Increases the [[sensitivity]] (compared to H&E alone).<ref name=pmid9170416>{{Cite journal | last1 = Beaugerie | first1 = L. | last2 = Cywiner-Golenzer | first2 = C. | last3 = Monfort | first3 = L. | last4 = Girard | first4 = PM. | last5 = Carbonnel | first5 = F. | last6 = Ngô | first6 = Y. | last7 = Cosnes | first7 = J. | last8 = Rozenbaum | first8 = W. | last9 = Nicolas | first9 = JC. | title = Definition and diagnosis of cytomegalovirus colitis in patients infected by human immunodeficiency virus. | journal = J Acquir Immune Defic Syndr Hum Retrovirol | volume = 14 | issue = 5 | pages = 423-9 | month = Apr | year = 1997 | doi = | PMID = 9170416 }}</ref> | |||
Others: | Others: | ||
| Line 31: | Line 69: | ||
*VZV. | *VZV. | ||
*[[EBV]]. | *[[EBV]]. | ||
===Images=== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354615/figure/f2-ijgm-8-097/ CMV colitis - IHC (nih.gov)].<ref name=pmid25767404>{{Cite journal | last1 = Harano | first1 = Y. | last2 = Kotajima | first2 = L. | last3 = Arioka | first3 = H. | title = Case of cytomegalovirus colitis in an immunocompetent patient: a rare cause of abdominal pain and diarrhea in the elderly. | journal = Int J Gen Med | volume = 8 | issue = | pages = 97-100 | month = | year = 2015 | doi = 10.2147/IJGM.S63771 | PMID = 25767404 }}</ref> | |||
==See also== | ==See also== | ||