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**Frequently looks just like [[colorectal adenocarcinoma]]. | **Frequently looks just like [[colorectal adenocarcinoma]]. | ||
*Without urothelial differentiation - '''essential'''.<ref name=pmid23451748>{{Cite journal | last1 = Zhong | first1 = M. | last2 = Gersbach | first2 = E. | last3 = Rohan | first3 = SM. | last4 = Yang | first4 = XJ. | title = Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. | journal = Arch Pathol Lab Med | volume = 137 | issue = 3 | pages = 371-81 | month = Mar | year = 2013 | doi = 10.5858/arpa.2012-0076-RA | PMID = 23451748 }}</ref> | *Without urothelial differentiation - '''essential'''.<ref name=pmid23451748>{{Cite journal | last1 = Zhong | first1 = M. | last2 = Gersbach | first2 = E. | last3 = Rohan | first3 = SM. | last4 = Yang | first4 = XJ. | title = Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. | journal = Arch Pathol Lab Med | volume = 137 | issue = 3 | pages = 371-81 | month = Mar | year = 2013 | doi = 10.5858/arpa.2012-0076-RA | PMID = 23451748 }}</ref> | ||
*+/-Evidence of invasion such as: | |||
**[[Desmoplastic stroma]]. | |||
**Extensive disordered or cribriform growth. | |||
Subtypes:<ref name=pmid23772302>{{Cite journal | last1 = Abbas | first1 = M. | last2 = Kramer | first2 = MW. | last3 = Wolters | first3 = M. | last4 = Herrman | first4 = TR. | last5 = Becker | first5 = JU. | last6 = Kreipe | first6 = HH. | title = Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case. | journal = Rare Tumors | volume = 5 | issue = 1 | pages = e3 | month = Feb | year = 2013 | doi = 10.4081/rt.2013.e3 | PMID = 23772302 }}</ref> | Subtypes:<ref name=pmid23772302>{{Cite journal | last1 = Abbas | first1 = M. | last2 = Kramer | first2 = MW. | last3 = Wolters | first3 = M. | last4 = Herrman | first4 = TR. | last5 = Becker | first5 = JU. | last6 = Kreipe | first6 = HH. | title = Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case. | journal = Rare Tumors | volume = 5 | issue = 1 | pages = e3 | month = Feb | year = 2013 | doi = 10.4081/rt.2013.e3 | PMID = 23772302 }}</ref> | ||
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*Signet ring cell carcinoma. | *Signet ring cell carcinoma. | ||
*Clear cell carcinoma (also ''[[mesonephroid carcinoma]]''). | *Clear cell carcinoma (also ''[[mesonephroid carcinoma]]''). | ||
Note: | |||
*The presence of [[adenocarcinoma in situ]] suggests the lesion arose in the bladder.{{fact}} | |||
DDx: | DDx: | ||
*[[Urachal | *[[Urachal adenocarcinoma]] - dome of bladder. | ||
*Invasive [[urothelial carcinoma]] with glandular differentiation - has urothelial differentiation. | *Invasive [[urothelial carcinoma]] with glandular differentiation - has urothelial differentiation. | ||
*[[Metastatic]] adenocarcinoma ''or'' extension of [[adenocarcinoma]] from a nearby structure | *[[Metastatic]] adenocarcinoma ''or'' extension of [[adenocarcinoma]] from a nearby structure |
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