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Difference between revisions of "Endolymphatic sac tumour"
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| Micro = Papillary epithelial structures. | | Micro = Papillary epithelial structures. | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[ | | LMDDx = [[choroid plexus papilloma]], metastatic [[adenocarcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = CK7 +ve | | IHC = CK7 +ve | ||
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| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = tinnitus, dizziness | ||
| Prevalence = very rare | | Prevalence = very rare | ||
| Bloodwork = | | Bloodwork = | ||
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| Tx = | | Tx = | ||
}} | }} | ||
'''Endolymphatic sac tumour''', abbreviated '''ELST''', is a very rare tumour associated with [[von Hippel-Lindau disease]]. | '''Endolymphatic sac tumour''', abbreviated '''ELST''', is a very rare tumour associated with [[von Hippel-Lindau disease]]. | ||
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DDx: | DDx: | ||
*Choroid plexus papilloma - when infiltrating cerebellopontine angle via petrous bone | *[[Choroid plexus papilloma]] - when infiltrating cerebellopontine angle via petrous bone. | ||
*Metastatic [[adenocarcinoma]] | *[[Metastatic]] [[adenocarcinoma]]. | ||
===Images=== | ===Images=== | ||
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==IHC== | ==IHC== | ||
*CK7 +ve | *CK7 +ve. | ||
*S-100 +ve (focally) | *S-100 +ve (focally). | ||
*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/> | *CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/> | ||
*Kir 7.1-ve - discriminates | *Kir 7.1 -ve - discriminates tumour from plexus papilloma.<ref name=pmid22706862>{{Cite journal | last1 = Schittenhelm | first1 = J. | last2 = Roser | first2 = F. | last3 = Tatagiba | first3 = M. | last4 = Beschorner | first4 = R. | title = Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors. | journal = Am J Clin Pathol | volume = 138 | issue = 1 | pages = 85-9 | month = Jul | year = 2012 | doi = 10.1309/AJCPPRKNNL09JTLP | PMID = 22706862 }}</ref> | ||
==See also== | ==See also== | ||
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[[Category:Head and neck pathology]] | [[Category:Head and neck pathology]] | ||
[[Category:Neuropathology]] | [[Category:Neuropathology]] | ||
[[Category:Papillary tumour]] | |||