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Difference between revisions of "Graft-versus-host disease"
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Graft-versus-host disease (view source)
Revision as of 04:54, 18 January 2011
, 04:54, 18 January 2011→Microscopic (skin)
(+skin changes) |
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Features:<ref name=stanford>{{cite web |url=http://surgpathcriteria.stanford.edu/transplant/skinacutegvhd/printable.html |title=Acute Graft versus Host Disease of the Skin |last1= |first1= |last2= |first2= |date= |work= |publisher= |accessdate=January 17, 2011}}</ref> | Features:<ref name=stanford>{{cite web |url=http://surgpathcriteria.stanford.edu/transplant/skinacutegvhd/printable.html |title=Acute Graft versus Host Disease of the Skin |last1= |first1= |last2= |first2= |date= |work= |publisher= |accessdate=January 17, 2011}}</ref> | ||
#Keratinocyte apoptosis. | #Keratinocyte apoptosis. | ||
#*Intensely eosinophilic on [[H&E]]. | |||
#Epidermotropic lymphocytic infiltrate = lymphocytes in the epidermis. | #Epidermotropic lymphocytic infiltrate = lymphocytes in the epidermis. | ||
#Vacuolar degeneration of basal and suprabasal cells in the epidermis. | #Vacuolar degeneration of basal and suprabasal cells in the epidermis. | ||
====Grading<ref name=stanford/>==== | ====Grading<ref name=stanford/>==== | ||
*Grade I: Only vacuolar changes, no apoptosis; not treated. | *Grade I: Only vacuolar changes, no apoptosis, no lymphocytes; '''not treated'''. | ||
*Grade II: Only scattered apoptotic cells. | *Grade II: Only scattered apoptotic cells. | ||
*Grade III: Focal separation/cleft formation at the dermal-epidermal junction. | *Grade III: Focal separation/cleft formation at the dermal-epidermal junction. | ||