Difference between revisions of "Extramammary Paget disease"

Extramammary Paget disease (view source)

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 *Differentiation markers GATA - apocrine and urothelial; p63 - squamous, CDX2 - colorectal
-Notice that a CK20 negative urothelial origin EMPD will show the same immunoprofile as a primary cutaneous EMPD.
+*Notice that a CK20 negative urothelial origin EMPD will show the same immunoprofile as a primary cutaneous EMPD.
-Notice that you do not need to consider mammary Paget disease or Toker cells in your ddx.
+*Notice that you do not need to include markers for mammary Paget disease or Toker cells.
 You can not rely on any one marker - a panel is required
 **Do not rely on CK7 alone as CK7 may be positive in pagetoid squamous cell carcinoma in situ or extramammary Paget disease <ref>{{Cite journal  | last1 = Raju | first1 = RR. | last2 = Goldblum | first2 = JR. | last3 = Hart | first3 = WR. | title = Pagetoid squamous cell carcinoma in situ (pagetoid Bowen's disease) of the external genitalia. | journal = Int J Gynecol Pathol | volume = 22 | issue = 2 | pages = 127-35 | month = Apr | year = 2003 | doi =  | PMID = 12649666 }}</ref>