Difference between revisions of "Adrenocortical carcinoma"

Adrenocortical carcinoma (view source)

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 ==Microscopic==
-Various criteria exist for this diagnosis.  The most widely used is the ''Weiss criteria'', which is a big long clunker.
+Various criteria exist for this diagnosis.  The most widely used is the ''Weiss criteria'', which is a big long clunker.  This area is prone to regular re-jiggering of criteria and a literature update or expert opinion is recommended prior to signing out one of these rare lesions.
 In general:
-Adenomas are small, circumscribed and have cells with largely bland nuclei and abundant foamy clear or pink cytoplasm.  Carcinomas are large, infiltrative, have fibrous bands and necrosis, and cells with less cytoplasm and more atypia.
+Cortical adenomas are small, circumscribed and have cells with largely bland nuclei and abundant foamy clear or pink cytoplasm.
+Adrenal carcinomas are large, infiltrative, have fibrous bands and necrosis, and cells with less cytoplasm and more atypia including atypical mitotic figures.
+Adrenal adenomas in children; however, can look really ugly.
 Notes: