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Difference between revisions of "C-cell hyperplasia"
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| Line 8: | Line 8: | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[medullary thyroid carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 14: | Line 14: | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = not apparent | ||
| Grossing = | | Grossing = | ||
| Site = [[thyroid gland]] | | Site = [[thyroid gland]] | ||
| Line 23: | Line 23: | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = uncommon | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = calcitonin level elevated | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Line 29: | Line 29: | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = | | Tx = prophylatic surgery | ||
}} | }} | ||
'''C-cell hyperplasia''' is a pathology of the [[thyroid gland]] and considered the precursor for [[medullary thyroid carcinoma]]. | '''C-cell hyperplasia''' is a pathology of the [[thyroid gland]] and considered the precursor for [[medullary thyroid carcinoma]]. | ||
| Line 36: | Line 36: | ||
*Screening for C-cell hyperplasia/[[medullary thyroid carcinoma]] done with ''serum calcitonin level''.<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | *Screening for C-cell hyperplasia/[[medullary thyroid carcinoma]] done with ''serum calcitonin level''.<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | ||
*Associated with [[multiple endocrine neoplasia type 2A]].<ref name=pmid21134882>{{Cite journal | last1 = Tyer | first1 = NM. | last2 = Braunstein | first2 = GD. | last3 = Frishberg | first3 = D. | title = Unusual case of multiple endocrine neoplasia type 2A syndrome without medullary thyroid carcinoma. | journal = Endocr Pract | volume = 17 | issue = 2 | pages = e4-7 | month = | year = | doi = 10.4158/EP10157.CR | PMID = 21134882 }}</ref> | *Associated with [[multiple endocrine neoplasia type 2A]].<ref name=pmid21134882>{{Cite journal | last1 = Tyer | first1 = NM. | last2 = Braunstein | first2 = GD. | last3 = Frishberg | first3 = D. | title = Unusual case of multiple endocrine neoplasia type 2A syndrome without medullary thyroid carcinoma. | journal = Endocr Pract | volume = 17 | issue = 2 | pages = e4-7 | month = | year = | doi = 10.4158/EP10157.CR | PMID = 21134882 }}</ref> | ||
**Finding done in a surgery done to exclude MTC in the context of [[MEN 2A]].<ref name=pmid18976013>{{Cite journal | last1 = Etit | first1 = D. | last2 = Faquin | first2 = WC. | last3 = Gaz | first3 = R. | last4 = Randolph | first4 = G. | last5 = DeLellis | first5 = RA. | last6 = Pilch | first6 = BZ. | title = Histopathologic and clinical features of medullary microcarcinoma and C-cell hyperplasia in prophylactic thyroidectomies for medullary carcinoma: a study of 42 cases. | journal = Arch Pathol Lab Med | volume = 132 | issue = 11 | pages = 1767-73 | month = Nov | year = 2008 | doi = 10.1043/1543-2165-132.11.1767 | PMID = 18976013 }}</ref> | |||
==Gross== | ==Gross== | ||
*Not visible. | *Not visible. | ||