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Renal cell carcinoma with sarcomatoid differentiation (view source)
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# | '''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial kidney tumour with malignant mesenchymal differentiation. | ||
These tumours are '''not''' recognized as a distinct type of renal cell carcinoma; they are classified by the non-sarcomatous component. If the tumour is purely sarcomatous and of renal origin it is ''[[renal cell carcinoma, unclassified]]''. | |||
'''Sarcomatoid renal cell carcinoma''', abbreviated '''sarcomatoid RCC''', redirects here. | |||
==General== | |||
Features:<ref name=pmid11224597>{{Cite journal | last1 = de Peralta-Venturina | first1 = M. | last2 = Moch | first2 = H. | last3 = Amin | first3 = M. | last4 = Tamboli | first4 = P. | last5 = Hailemariam | first5 = S. | last6 = Mihatsch | first6 = M. | last7 = Javidan | first7 = J. | last8 = Stricker | first8 = H. | last9 = Ro | first9 = JY. | title = Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. | journal = Am J Surg Pathol | volume = 25 | issue = 3 | pages = 275-84 | month = Mar | year = 2001 | doi = | PMID = 11224597 }}</ref> | |||
*Not recognized as a distinct entity in 2004 WHO classification.<ref name=pmid16442207>{{Cite journal | last1 = Lopez-Beltran | first1 = A. | last2 = Scarpelli | first2 = M. | last3 = Montironi | first3 = R. | last4 = Kirkali | first4 = Z. | title = 2004 WHO classification of the renal tumors of the adults. | journal = Eur Urol | volume = 49 | issue = 5 | pages = 798-805 | month = May | year = 2006 | doi = 10.1016/j.eururo.2005.11.035 | PMID = 16442207 }}</ref> | |||
**It is considered an indicator of progression. | |||
**Previously considered a distinct entity.<ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal | last1 = Cangiano | first1 = T. | last2 = Liao | first2 = J. | last3 = Naitoh | first3 = J. | last4 = Dorey | first4 = F. | last5 = Figlin | first5 = R. | last6 = Belldegrun | first6 = A. | title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. | journal = J Clin Oncol | volume = 17 | issue = 2 | pages = 523-8 | month = Feb | year = 1999 | doi = | PMID = 10080595 | URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref> | |||
*Tend to present at higher stage. | |||
*Worse prognosis when adjusted for stage. | |||
*[[Fuhrman grade]] 4 by definition. | |||
==Microscopic== | |||
Features:<ref name=pmid11224597/> | |||
#Renal cell carcinoma. | |||
#Sarcomatoid component: | |||
#*[[Fibrosarcoma]] - most common. | |||
#*[[Pleomorphic undifferentiated sarcoma|Undifferentiated]] - common. | |||
#*[[Rhabdomyosarcoma]] - very rare. | |||
Notes: | |||
*In essence, any kidney tumour with [[spindle cell]]s should make one think of this.<ref name=pmid15763002/> | |||
*[[Renal cell carcinoma with rhabdoid morphology|Rhabdoid change in renal cell carcinoma]] is probably analogous to sarcomatoid change.<ref name=pmid21665507>{{Cite journal | last1 = Chapman-Fredricks | first1 = JR. | last2 = Herrera | first2 = L. | last3 = Bracho | first3 = J. | last4 = Gomez-Fernandez | first4 = C. | last5 = Leveillee | first5 = R. | last6 = Rey | first6 = L. | last7 = Jorda | first7 = M. | title = Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 333-7 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.002 | PMID = 21665507 }}</ref> | |||
Images: | |||
*[http://webpathology.com/image.asp?n=2&Case=70 Sarcomatoid change in RCC (webpathology.com)]. | |||
*[http://jco.ascopubs.org/content/27/2/235/F1.expansion Sarcomatoid changes in CCRCC (ascopubs.org)].<ref name=pmid19064974>{{Cite journal | last1 = Golshayan | first1 = AR. | last2 = George | first2 = S. | last3 = Heng | first3 = DY. | last4 = Elson | first4 = P. | last5 = Wood | first5 = LS. | last6 = Mekhail | first6 = TM. | last7 = Garcia | first7 = JA. | last8 = Aydin | first8 = H. | last9 = Zhou | first9 = M. | title = Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. | journal = J Clin Oncol | volume = 27 | issue = 2 | pages = 235-41 | month = Jan | year = 2009 | doi = 10.1200/JCO.2008.18.0000 | PMID = 19064974 }}</ref> | |||
*[http://www.scielo.br/img/revistas/ibju/v31n1/1a03f1.jpg Sarcomatoid changes in RCC (scielo.br)].<ref name=pmid15763002>{{Cite journal | last1 = Dall'Oglio | first1 = MF. | last2 = Lieberknecht | first2 = M. | last3 = Gouveia | first3 = V. | last4 = Sant'Anna | first4 = AC. | last5 = Leite | first5 = KR. | last6 = Srougi | first6 = M. | title = Sarcomatoid differentiation in renal cell carcinoma: prognostic implications. | journal = Int Braz J Urol | volume = 31 | issue = 1 | pages = 10-6 | month = | year = | doi = | PMID = 15763002 }}</ref> | |||
==See also== | |||
*[[Kidney tumours]]. | |||
*[[Renal cell carcinoma with rhabdoid change]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Kidney tumours]] | |||