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| ====Histologic terms==== | | ====Histologic terms==== |
| *Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma. | | *Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma. |
| *Auer rods = Acute myeloid leukemia. | | *[[Auer rods]] = [[acute myeloid leukemia]]. |
| **Granular cytoplasmic rod (0.5-1 x4-6 micrometres). | | **Granular cytoplasmic rod (0.5-1 x4-6 micrometres). |
| | **Not pathognomonic. |
| *Reed-Sternberg cells = [[Hodgkin's lymphoma]]. | | *Reed-Sternberg cells = [[Hodgkin's lymphoma]]. |
| **Large cell - very large nucleus. | | **Large cell - very large nucleus. |
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| Others: | | Others: |
| *AE1/AE3 -- to r/o carcinoma. | | *[[AE1/AE3]] -ve -- to r/o carcinoma. |
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| ====T cell markers==== | | ====T cell markers==== |
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| Features: | | Features: |
| *Intermediate size cells with: | | *Intermediate size cells with: |
| **+/-Vesicular nuclei. | | **+/-[[Vesicular nuclei]]. |
| **Clear, moderate cytoplasm. | | **Clear, moderate cytoplasm. |
| *"Empty" sinus; subcapsular sinuses "open". | | *"Empty" sinus; subcapsular sinuses "open". |
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| *[[AKA]] ''extranodal natural kill lymphoma'' | | *[[AKA]] ''extranodal natural kill lymphoma'' |
| *[[AKA]] ''angiocentric lymphoma''. | | *[[AKA]] ''angiocentric lymphoma''. |
| | | {{Main|Extranodal NK/T-cell lymphoma, nasal type}} |
| ===General===
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| *Common in east Asia.<ref name=pmid18283711>{{Cite journal | last1 = Suzuki | first1 = R. | last2 = Takeuchi | first2 = K. | last3 = Ohshima | first3 = K. | last4 = Nakamura | first4 = S. | title = Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. | journal = Hematol Oncol | volume = 26 | issue = 2 | pages = 66-72 | month = Jun | year = 2008 | doi = 10.1002/hon.847 | PMID = 18283711 }}</ref>
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| *Strong association with [[EBV]].
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| ===Microscopic===
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| Features:
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| *Atypical lymphoid cells:
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| **[[Nucleoli]].
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| **[[Nuclear pleomorphism]].
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| **Cells centered around vessels (angiocentric).
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| ***May destroy small and medium sized arterioles.
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| Images:
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| *[http://path.upmc.edu/cases/case231/micro.html Extranodal NK/T-cell lymphoma, nasal type - case 1 - several images (upmc.edu)].
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| *[http://path.upmc.edu/cases/case310.html Extranodal NK/T-cell lymphoma, nasal type - case 2 - several images (upmc.edu)].
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| ===IHC===
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| Features:<ref name=pmid17064952>{{Cite journal | last1 = Al-Hakeem | first1 = DA. | last2 = Fedele | first2 = S. | last3 = Carlos | first3 = R. | last4 = Porter | first4 = S. | title = Extranodal NK/T-cell lymphoma, nasal type. | journal = Oral Oncol | volume = 43 | issue = 1 | pages = 4-14 | month = Jan | year = 2007 | doi = 10.1016/j.oraloncology.2006.03.011 | PMID = 17064952 }}</ref>
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| *CD2 +ve.
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| *CD3 +ve (cytoplasmic).
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| *[[CD56]] +ve.
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| Others:<ref>URL: [http://path.upmc.edu/cases/case310.html http://path.upmc.edu/cases/case310.html]. Accessed on: 14 January 2012.</ref>
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| *TIA-1 +ve.
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| *CD7 +ve.
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| *EBER +ve.
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| ==Table of lymphoma== | | ==Table of lymphoma== |