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Difference between revisions of "Neuropathology tumours"
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Neuropathology tumours (view source)
Revision as of 05:45, 14 December 2014
, 05:45, 14 December 2014→Common neuropathology tumours in a table: +GBM, re-order table
(→Common neuropathology tumours in a table: +GBM, re-order table) |
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|[[Image:Reactive_astrocytes_-_lfb_-_high_mag.jpg|thumb|center|150px|Reactive astrocytes. (WC)]] | |[[Image:Reactive_astrocytes_-_lfb_-_high_mag.jpg|thumb|center|150px|Reactive astrocytes. (WC)]] | ||
|- | |- | ||
|[[ | |[[Schwannoma]] | ||
|glial processes (esp. on smear), nuclear atypia (size var. ~3x, irreg. nuc. membrane, hyperchromasia), no Rosenthal fibres in the core of the lesion † | |cellular areas (Antoni A), paucicelluar areas (Antoni B), palisading of nuclei (Verocay bodies) | ||
|extra-axial + intradural | |||
|old or young | |||
|need frozen section to Dx, DDx: [[meningioma]] | |||
|S100 | |||
|[[Image:Schwannoma_-_Antoni_A_and_B_-_very_high_mag.jpg|thumb|center|150px|Schwannoma. (WC)]] | |||
|- | |||
|[[Meningioma]] | |||
|whorls, psammomatous calcs, nuclear inclusions | |||
|extra-axial + intradural | |||
|old or young | |||
|may be diagnosed on smear, DDx: [[schwannoma]], choroid plexus | |||
|EMA, PR, Ki-67 | |||
|[[Image:Meningioma_intermed_mag.jpg |thumb|center|150px|Meningioma. (WC)]] | |||
|- | |||
|Infiltrative [[astrocytoma]] ([[WHO]] grade II or grade III) | |||
|glial processes (esp. on smear), nuclear atypia (typical size var. ~3x, irreg. nuc. membrane, hyperchromasia), no Rosenthal fibres in the core of the lesion †, no microvascular proliferation, no necrosis | |||
|often enhancing (suggests high grade), usu. supratentorial, usu. white matter | |||
|usu. old, occ. young | |||
|common | |||
|IDH-1+/-, GFAP+ | |||
| [[Image:Anaplastic_astrocytoma_-_very_high_mag_-_cropped.jpg | thumb| center| 150px|High-grade astrocytoma. (WC)]] | |||
|- | |||
|[[Glioblastoma]] (WHO grade IV) | |||
|glial processes (esp. on smear), nuclear atypia (typical size var. ~3x, irreg. nuc. membrane, hyperchromasia), no Rosenthal fibres in the core of the lesion †, microvascular proliferation or necrosis | |||
|often enhancing (suggests high grade), usu. supratentorial, usu. white matter | |often enhancing (suggests high grade), usu. supratentorial, usu. white matter | ||
|usu. old, occ. young | |usu. old, occ. young | ||
|very common, esp. glioblastoma | |very common, esp. glioblastoma | ||
|IDH-1+/-, GFAP+ | |IDH-1+/-, GFAP+ | ||
| [[Image: | | [[Image:Glioblastoma (1).jpg | thumb| center| 150px|Glioblastoma. (WC)]] | ||
|- | |- | ||
|[[Metastatic brain tumours|Metastasis]] | |[[Metastatic brain tumours|Metastasis]] | ||
| Line 129: | Line 153: | ||
|[[TTF-1]], CK7, [[CK20]], BRST-2 | |[[TTF-1]], CK7, [[CK20]], BRST-2 | ||
|[[Image:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg | thumb| center|150px |Metastasis. (WC)]] | |[[Image:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg | thumb| center|150px |Metastasis. (WC)]] | ||
|} | |} | ||
† Rosenthal fibres at the periphery of a lesion are a non-specific finding seen in chronic processes. | † Rosenthal fibres at the periphery of a lesion are a non-specific finding seen in chronic processes. | ||