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*[[AKA]] ''nested variant urothelial cell carcinoma''. | *[[AKA]] ''nested variant urothelial cell carcinoma''. | ||
===General=== | |||
*Aggressive behaviour despite bland histomorphology.<ref name=pmid14681330>{{Cite journal | last1 = Lin | first1 = O. | last2 = Cardillo | first2 = M. | last3 = Dalbagni | first3 = G. | last4 = Linkov | first4 = I. | last5 = Hutchinson | first5 = B. | last6 = Reuter | first6 = VE. | title = Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. | journal = Mod Pathol | volume = 16 | issue = 12 | pages = 1289-98 | month = Dec | year = 2003 | doi = 10.1097/01.MP.0000094091.04541.FC | PMID = 14681330 }}</ref> | |||
===Microscopic=== | |||
Features:<ref name=pmid2712189>{{Cite journal | last1 = Talbert | first1 = ML. | last2 = Young | first2 = RH. | title = Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. | journal = Am J Surg Pathol | volume = 13 | issue = 5 | pages = 374-81 | month = May | year = 1989 | doi = | PMID = 2712189 }}</ref> | Features:<ref name=pmid2712189>{{Cite journal | last1 = Talbert | first1 = ML. | last2 = Young | first2 = RH. | title = Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. | journal = Am J Surg Pathol | volume = 13 | issue = 5 | pages = 374-81 | month = May | year = 1989 | doi = | PMID = 2712189 }}</ref> | ||
*High density of well-circumscribed nests. | *High density of well-circumscribed nests. | ||
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*[[von Brunn nests]]. | *[[von Brunn nests]]. | ||
*[[Low grade papillary urothelial carcinoma]] with lamina propria invasion. | *[[Low grade papillary urothelial carcinoma]] with lamina propria invasion. | ||
===IHC=== | |||
*MIB-1 typically >15%.<ref name=pmid14681330/> | |||
=See also= | =See also= |
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