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Dysembryoplastic neuroepithelial tumour (view source)
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'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNT'', is a rare [[neuropathology tumour]] that is associated with [[epilepsy]]. | |||
==General== | |||
*Common tumour cause of drug resistant [[epilepsy]].<ref name=pmid15881751>{{Cite journal | last1 = Cataltepe | first1 = O. | last2 = Turanli | first2 = G. | last3 = Yalnizoglu | first3 = D. | last4 = Topçu | first4 = M. | last5 = Akalan | first5 = N. | title = Surgical management of temporal lobe tumor-related epilepsy in children. | journal = J Neurosurg | volume = 102 | issue = 3 Suppl | pages = 280-7 | month = Apr | year = 2005 | doi = 10.3171/ped.2005.102.3.0280 | PMID = 15881751 }}</ref> | |||
*Paediatric population. | |||
==Gross/radiology== | |||
*Temporal lobe. | |||
*Variable architecture:<ref name=pmid18071981/> cystic, solitary nodular, multinodular. | |||
==Microscopic== | |||
Features:<ref name=pmid18071981>{{Cite journal | last1 = O'Brien | first1 = DF. | last2 = Farrell | first2 = M. | last3 = Delanty | first3 = N. | last4 = Traunecker | first4 = H. | last5 = Perrin | first5 = R. | last6 = Smyth | first6 = MD. | last7 = Park | first7 = TS. | title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. | journal = Br J Neurosurg | volume = 21 | issue = 6 | pages = 539-49 | month = Dec | year = 2007 | doi = 10.1080/02688690701594817 | PMID = 18071981 }}</ref> | |||
*Cells similar to oligodendrocytes: | |||
**Large central nuclei with indentations. | |||
**Multiple small nucleoli (common). | |||
**Clear cytoplasm. | |||
DDx: | |||
*[[Oligodendroglioma]]. | |||
**These have rounder, smaller nuclei with occasional nucleoli.<ref name=pmid18071981/> | |||
===Images=== | |||
<gallery> | |||
Image:DNET_HE.jpg | DNT (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case106.html DNT - several images (upmc.edu)]. | |||
==See also== | |||
*[[Neuropathology tumours]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | |||