Difference between revisions of "Uterine tumours"

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Uterine tumours (view source)

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→‎Uterine carcinosarcoma: split out
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==Uterine carcinosarcoma==
==Uterine carcinosarcoma==
* [[AKA]] ''malignant mixed muellerian tumour'', abbreviated ''MMMT''.
* [[AKA]] ''malignant mixed muellerian tumour'', abbreviated ''MMMT''.
 
{{Main|Uterine carcinosarcoma}}
===General===
* Associated with previous radiation exposure.
* Metstasize as adenocarcinoma.
* Aggressive/poor prognosis;<ref name=pmid15688674>{{Cite journal  | last1 = Ivy | first1 = JJ. | last2 = Unger | first2 = JB. | title = Malignant mixed mullerian sarcomas of the uterus--the LSUHSC Shreveport experience. | journal = J La State Med Soc | volume = 156 | issue = 6 | pages = 324-6 | month =  | year =  | doi =  | PMID = 15688674 }}</ref> in one series 5 year survival ~= 30-35%.<ref name=pmid14967435>{{Cite journal  | last1 = Callister | first1 = M. | last2 = Ramondetta | first2 = LM. | last3 = Jhingran | first3 = A. | last4 = Burke | first4 = TW. | last5 = Eifel | first5 = PJ. | title = Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. | journal = Int J Radiat Oncol Biol Phys | volume = 58 | issue = 3 | pages = 786-96 | month = Mar | year = 2004 | doi = 10.1016/S0360-3016(03)01561-X | PMID = 14967435 }}</ref>
*Considered to be a poorly differentiated endometrial carcinoma with metaplastic changes.<ref name=pmid19853898>{{Cite journal  | last1 = D'Angelo | first1 = E. | last2 = Prat | first2 = J. | title = Uterine sarcomas: a review. | journal = Gynecol Oncol | volume = 116 | issue = 1 | pages = 131-9 | month = Jan | year = 2010 | doi = 10.1016/j.ygyno.2009.09.023 | PMID = 19853898 }}</ref>
*Case reports of MMMT in [[ovary]] and [[fallopian tube]].
 
===Microscopic===
Features:<ref name=Ref_WMSP428>{{Ref WMSP|428}}</ref>
*Biphasic tumour:
*#Malignant glandular component (adenocarcinoma).
*#Malignant stromal component (one of the following):
*#*Homologous type (tissue native to uterus):
*#*#Smooth muscle ([[leiomyosarcoma]]).
*#*#Fibrous tissue ([[fibrosarcoma]]).
*#*Heterologous type (tissue not native to the uterus):
*#*#Skeletal muscle ([[rhabdomyosarcoma]]).
*#*#Cartilage ([[chondrosarcoma]]).
*#*#Bone ([[osteosarcoma]]).
*#*Undifferentiated sarcoma ([[pleomorphic undifferentiated sarcoma]]).
 
DDx:
*[[Undifferentiated endometrial sarcoma]].
*[[Adenosarcoma of the uterus]].
 
====Images====
<gallery>
Image:Carcinosarcoma_-_low_mag.jpg | MMMT - low mag. (WC)
Image:Carcinosarcoma_-_high_mag.jpg | MMMT - high mag. (WC)
Image:MalignantMixedMullerianTumor.JPG | MMMT - crappy (WC)
</gallery>
www:
*[http://path.upmc.edu/cases/case227.html MMMT - case 1 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case328.html MMMT - case 2 - several images (upmc.edu)].


==Adenosarcoma of the uterus==
==Adenosarcoma of the uterus==
Michael
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