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Difference between revisions of "Dermatologic neoplasms"
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→Melanoma
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**An epitheloid cell morphology may mimic adenocarcinoma. | **An epitheloid cell morphology may mimic adenocarcinoma. | ||
**A spindle cell morphology may mimic spindle cell carcinoma (squamous cell carcinoma) or a sarcoma. | **A spindle cell morphology may mimic spindle cell carcinoma (squamous cell carcinoma) or a sarcoma. | ||
===Electron microscopy=== | ===Electron microscopy=== | ||
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Image(s): | Image(s): | ||
*[http://www.nature.com/nrm/journal/v8/n10/fig_tab/nrm2258_F1.html Melanosomes (nature.com)]. | *[http://www.nature.com/nrm/journal/v8/n10/fig_tab/nrm2258_F1.html Melanosomes (nature.com)]. | ||
===Stains=== | |||
*''Fontana-Masson stain'', stains melanin.<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | |||
**May be useful to differentiate melanin from other brown stuff (e.g. lipofuscin, hemosiderin). | |||
===[[IHC]]=== | ===[[IHC]]=== | ||
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*HMB-45 +ve. | *HMB-45 +ve. | ||
*Melan A (MART-1) +ve. | *Melan A (MART-1) +ve. | ||
Others: | |||
*SOX10 +ve -- useful for diff. from excision scar.<ref name=pmid20653825>{{cite journal |author=Ramos-Herberth FI, Karamchandani J, Kim J, Dadras SS |title=SOX10 immunostaining distinguishes desmoplastic melanoma from excision scar |journal=J. Cutan. Pathol. |volume=37 |issue=9 |pages=944–52 |year=2010 |month=September |pmid=20653825 |doi=10.1111/j.1600-0560.2010.01568.x |url=}}</ref> | |||
Notes: | Notes: | ||
*The standard panel above is positive in other lesions | *The standard panel above (S-100, HMB-45, MART-1) is also positive in other lesions, e.g. ''cellular blue nevus''. | ||
==Dermatofibrosarcoma protuberans== | ==Dermatofibrosarcoma protuberans== | ||