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Difference between revisions of "Metaphyseal fibrous defect"
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Metaphyseal fibrous defect (view source)
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'''Metaphyseal fibrous defect''', abbreviated '''MFD''', is a common benign abnormality of the [[metaphysis]], classically seen in children and young adults. | |||
They are also known as '''fibrous cortical defect''', '''fibrous metaphyseal defect''', and '''fibroxanthoma of [[bone]]'''. '''Nonossifying fibroma''' is a larger lesion but otherwise identical. | |||
==General== | ==General== | ||
*Common | *Common. | ||
*Non-neoplastic | *Non-neoplastic. | ||
*Self-limited | *Self-limited. | ||
*Skeletally immature individuals, children and | *Skeletally immature individuals, children and adolescents. | ||
*Often small lesions discovered as an radiographic incidentaloma | *Often small lesions discovered as an radiographic incidentaloma. | ||
*Rarely seen as a pathologic specimen (should not be biopsied) | *Rarely seen as a pathologic specimen (should not be biopsied). | ||
==Site== | ==Site== | ||
*Metaphysis of distal femur or proximal tibia (80%) | *Metaphysis of distal femur or proximal tibia (80%). | ||
*Cortical | *Cortical. | ||
*Metaphysis | *[[Metaphysis]]. | ||
*Long bones | *Long bones. | ||
*Eccentric location | *Eccentric location. | ||
==Gross== | ==Gross== | ||
Firm, granular, brown to yellow to red | Firm, granular, brown to yellow to red. | ||
==Microscopic== | ==Microscopic== | ||
Spindle cells without cytologic atypia are arranged in a storiform pattern | Features: | ||
*Spindle cells without cytologic atypia are arranged in a storiform pattern. | |||
*Scattered chronic inflammatory cells and benign [[giant cell]]s. | |||
*Foam cells and hemosiderin deposition are present. | |||
*Mitoses are seen but cytologic atypia is absent. | |||
DDx (microscopic): | |||
*[[Giant cell tumour of bone]] | *[[Giant cell tumour of bone]] - [[epiphysis|epiphyseal]] location, occurs in adults. | ||
==Relevant Diagnostic Groups== | ==Relevant Diagnostic Groups== | ||