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Difference between revisions of "Vasculitides"
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*Giant cell arteritis (AKA ''temporal arteritis''). | *Giant cell arteritis (AKA ''temporal arteritis''). | ||
*Takayasu's arteritis. | *Takayasu's arteritis. | ||
Notes: | |||
*ANCA = anti-neutrophil cytoplasmic antibodies. | |||
==Giant cell arteritis== | ==Giant cell arteritis== | ||
| Line 36: | Line 39: | ||
Treatment: | Treatment: | ||
*Treat right away with high dose steroids. | *Treat right away with high dose steroids. | ||
===Micrograph=== | |||
Features: | |||
*Classical: granulomas. | |||
==Takayasu's arteritis== | ==Takayasu's arteritis== | ||
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*Granulomas, giant cells. | *Granulomas, giant cells. | ||
*+/-Patchy necrosis of media. | *+/-Patchy necrosis of media. | ||
==Polyarteritis nodosa== | |||
*Abbreviated ''PAN'' | |||
*Involves small and medium sized vessels. | |||
*Often - renal vessels, mesenteric vessels.<ref>Klatt. AOP P.14.</ref> | |||
*Strong association with ''hepatitis B'' (see [[medical liver diseases]]); ~1/3 of patients with PAN have HBV. | |||
Serology: | |||
*ANCA is usually negative. | |||
===Microscopic=== | |||
Features: | |||
*Inflammatory cells (neutrophils, lymphocytes) within the tunica media. | |||
*Necrosis: dead vessel wall - pink anucleate stuff, nuclear debris (black specks of nuclear material). | |||
==Wegener's granulomatosis== | |||
*Nasal cavity. | |||
*Renal. | |||
*Pulmonary hemorrhage | |||
Notes: | |||
*Pulmonary hemorrhage syndromes:<ref>PBoD p.745.</ref> | |||
**Goodpasture. | |||
**Idiopathic pulmonary hemosiderosis. | |||
**Vasculitis-assoc. hemorrhage (hypersensitivity angiitis, Wegener's granulomatosis). | |||
**Systemic lupus erythematosus. | |||
===Microscopic=== | |||
Features: | |||
*Granulomas typically poorly formed.<ref>PBoD p.747.</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Cardiovascular pathology]] | |||