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Difference between revisions of "Neuropathology tumours"
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Neuropathology tumours (view source)
Revision as of 14:20, 22 December 2010
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DDx: Embryonal tumor with abundant neuropil and true rosettes (ETANTR).<ref>{{cite journal |author=Buccoliero AM, Castiglione F, Degl'Innocenti DR, ''et al.'' |title=Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation |journal=Neuropathology |volume=30 |issue=1 |pages=84–91 |year=2010 |month=February |pmid=19563506 |doi=10.1111/j.1440-1789.2009.01040.x |url=}}</ref> | DDx: Embryonal tumor with abundant neuropil and true rosettes (ETANTR).<ref>{{cite journal |author=Buccoliero AM, Castiglione F, Degl'Innocenti DR, ''et al.'' |title=Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation |journal=Neuropathology |volume=30 |issue=1 |pages=84–91 |year=2010 |month=February |pmid=19563506 |doi=10.1111/j.1440-1789.2009.01040.x |url=}}</ref> | ||
==CNS lymphoma== | |||
Classification: | |||
*Primary CNS lymphoma. | |||
*Non-primary CNS lymphoma - see ''[[lymphoma]]'' article. | |||
===General - primary CNS=== | |||
*Classically periventicular distribution. | |||
*Usually large B cell; can be considered a type of [[diffuse large B cell lymphoma]] (DLBCL). | |||
**Prognosis of CNS (DLBCL) lymphomas worse than nodal (non-CNS) DLBCL.<ref name=pmid19925562>{{cite journal |author=Raoux D, Duband S, Forest F, ''et al.'' |title=Primary central nervous system lymphoma: Immunohistochemical profile and prognostic significance |journal=Neuropathology |volume=30 |issue=3 |pages=232–40 |year=2010 |month=June |pmid=19925562 |doi=10.1111/j.1440-1789.2009.01074.x |url=}}</ref> | |||
===Microscopic=== | |||
Features: | |||
*Large cell lymphoma. | |||
**Size = 2x diameter normal lymphocyte. | |||
**Nucleolus - common. | |||
*Perivascular clustering. | |||
===IHC=== | |||
Can be subclassified in ''GCB (germinal centre B-cell-like)'' and ''non-GCB'' by CD10, Bcl-6, MUM1/IRF-4, and Bcl-2.<ref name=pmid19925562/> | |||
Common pattern: | |||
*CD20 +ve - key stain. | |||
*CD3 -ve. | |||
*Ki-67 ~40%. | |||
*Bcl-6 +ve. | |||
*Bcl-1 -ve. | |||
==See also== | ==See also== | ||