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Difference between revisions of "Immune thrombocytopenic purpura"
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid4044880>{{cite journal |author=Hayes MM, Jacobs P, Wood L, Dent DM |title=Splenic pathology in immune thrombocytopenia |journal=J. Clin. Pathol. |volume=38 |issue=9 |pages=985–8 |year=1985 |month=September |pmid=4044880 |pmc=499346 |doi= |url=}}</ref> | Features:<ref name=pmid4044880>{{cite journal |author=Hayes MM, Jacobs P, Wood L, Dent DM |title=Splenic pathology in immune thrombocytopenia |journal=J. Clin. Pathol. |volume=38 |issue=9 |pages=985–8 |year=1985 |month=September |pmid=4044880 |pmc=499346 |doi= |url=}}</ref> | ||
* | *Germinal centres in white pulp (~55% of cases) | ||
**Classically described as "proliferative". | |||
*Neutrophils in the red pulp (~67% of cases). | *Neutrophils in the red pulp (~67% of cases). | ||
*Macrophages in the red pulp (~25% of cases). † | |||
Notes: | |||
*Changes not dependent on titre of antiplatelet antibodies.<ref name=pmid4044880/> | |||
*† May be a finding associated with treatment.<ref name=pmid4044880/> | |||
*The classic changes are ''proliferation of lymphoid germinal centres'' and red pulp [[PMN]]s. | |||
===Images=== | ===Images=== | ||