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**A small focus of HGPIN does not appear to be associated with an increased risk for prostate cancer on re-biopsy at one year if the initial biopsy had 8 or more cores.<ref name=pmid16406886>{{Cite journal | last1 = Herawi | first1 = M. | last2 = Kahane | first2 = H. | last3 = Cavallo | first3 = C. | last4 = Epstein | first4 = JI. | title = Risk of prostate cancer on first re-biopsy within 1 year following a diagnosis of high grade prostatic intraepithelial neoplasia is related to the number of cores sampled. | journal = J Urol | volume = 175 | issue = 1 | pages = 121-4 | month = Jan | year = 2006 | doi = 10.1016/S0022-5347(05)00064-9 | PMID = 16406886 }}</ref> | **A small focus of HGPIN does not appear to be associated with an increased risk for prostate cancer on re-biopsy at one year if the initial biopsy had 8 or more cores.<ref name=pmid16406886>{{Cite journal | last1 = Herawi | first1 = M. | last2 = Kahane | first2 = H. | last3 = Cavallo | first3 = C. | last4 = Epstein | first4 = JI. | title = Risk of prostate cancer on first re-biopsy within 1 year following a diagnosis of high grade prostatic intraepithelial neoplasia is related to the number of cores sampled. | journal = J Urol | volume = 175 | issue = 1 | pages = 121-4 | month = Jan | year = 2006 | doi = 10.1016/S0022-5347(05)00064-9 | PMID = 16406886 }}</ref> | ||
Low-grade prostatic intraepithelial neoplasia: | |||
*Should ''not'' be reported.<ref name=pmid16469560>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Herawi | first2 = M. | title = Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care. | journal = J Urol | volume = 175 | issue = 3 Pt 1 | pages = 820-34 | month = Mar | year = 2006 | doi = 10.1016/S0022-5347(05)00337-X | PMID = 16469560 }}</ref> | |||
*Believed to be irrelevant biologically/clinically. | |||
**''PIN'' not otherwise specified refers to ''HGPIN''. | |||
**Low-grade PIN has the architecture of HGPIN but lacks the nuclear atypia. | |||
===HGPIN and cancer on follow-up biopsy=== | ===HGPIN and cancer on follow-up biopsy=== |
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