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| Caption = Hyperplastic polyp. [[H&E stain]]. | | Caption = Hyperplastic polyp. [[H&E stain]]. | ||
| Micro = serrated architecture at the surface without glandular abnormalities | | Micro = serrated architecture at the surface without glandular abnormalities | ||
| Subtypes = microvesicular serrated polyps (MVSPs), goblet cell serrated polyps (GCSPs) | | Subtypes = microvesicular serrated polyps (MVSPs), goblet cell serrated polyps (GCSPs) | ||
| LMDDx = [[sessile serrated adenoma]], [[normal colon]], other [[gastrointestinal polyps]] | | LMDDx = [[sessile serrated adenoma]], [[normal colon]], [[hyperplastic polyp with perineuromatous stroma]], other [[gastrointestinal polyps]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = [[Chromogranin A]] +ve (increased scattered Chromogranin A-positive cells in relation to normal mucosa) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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*[[Normal colon]]. | *[[Normal colon]]. | ||
*[[Colorectal xanthomatous polyp|Xanthomatous polyp]] with hyperplastic features.<ref name=pmid14961968>{{Cite journal | last1 = Nakasono | first1 = M. | last2 = Hirokawa | first2 = M. | last3 = Muguruma | first3 = N. | last4 = Okahisa | first4 = T. | last5 = Okamura | first5 = S. | last6 = Ito | first6 = S. | last7 = Miyamoto | first7 = H. | last8 = Wada | first8 = S. | last9 = Fukuda | first9 = T. | title = Colorectal xanthomas with polypoid lesion: report of 25 cases. | journal = APMIS | volume = 112 | issue = 1 | pages = 3-10 | month = Jan | year = 2004 | doi = | PMID = 14961968 }}</ref> | *[[Colorectal xanthomatous polyp|Xanthomatous polyp]] with hyperplastic features.<ref name=pmid14961968>{{Cite journal | last1 = Nakasono | first1 = M. | last2 = Hirokawa | first2 = M. | last3 = Muguruma | first3 = N. | last4 = Okahisa | first4 = T. | last5 = Okamura | first5 = S. | last6 = Ito | first6 = S. | last7 = Miyamoto | first7 = H. | last8 = Wada | first8 = S. | last9 = Fukuda | first9 = T. | title = Colorectal xanthomas with polypoid lesion: report of 25 cases. | journal = APMIS | volume = 112 | issue = 1 | pages = 3-10 | month = Jan | year = 2004 | doi = | PMID = 14961968 }}</ref> | ||
*[[Hyperplastic polyp with perineuromatous stroma]]. | |||
===Images=== | ===Images=== | ||
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| Goblet cell | | Goblet cell | ||
| superficial goblet cells, serration at <br>the surface | | superficial goblet cells, serration at <br>the surface | ||
| KRAS | | [[KRAS mutation|KRAS]] | ||
| unknown; probably benign | | unknown; probably benign | ||
|} | |} | ||
Notes: | Notes: | ||
*CIMP = CpG island methylation phenotype. | *CIMP = CpG island methylation phenotype. | ||
==IHC== | |||
*[[Chromogranin A]] increased scattered Chromogranin A-positive cells (in relation to normal colorectal mucosa). | |||
**[[Sessile serrated adenoma]] is completely negative for [[Chromogranin A]]. | |||
==Sign out== | ==Sign out== | ||
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*[[Gastrointestinal tract polyps]]. | *[[Gastrointestinal tract polyps]]. | ||
*[[Gastrointestinal pathology]]. | *[[Gastrointestinal pathology]]. | ||
*[[Hyperplastic polyp with perineuromatous stroma]]. | |||
==References== | ==References== |
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