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Difference between revisions of "Pulmonary alveolar proteinosis"
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Pulmonary alveolar proteinosis (view source)
Revision as of 21:18, 26 February 2014
, 21:18, 26 February 2014+infobox
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Pulmonary_alveolar_proteinosis_-3-_intermed_mag.jpg | |||
| Width = | |||
| Caption = Pulmonary alveolar proteinosis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = acellular eosinophilic crap in the alveoli with "dense bodies" or "chatter" (represent dead macrophages) | |||
| Subtypes = | |||
| LMDDx = [[pulmonary edema]], [[pneumocystis pneumonia]], [[pulmonary hemorrhage]] (acute) | |||
| Stains = PAS +ve | |||
| IHC = surfactant +ve | |||
| EM = lamellar bodies | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lung]] - see ''[[medical lung diseases]]'' | |||
| Assdx = +/-hematologic malignancy | |||
| Syndromes = | |||
| Clinicalhx = +/-infection | |||
| Signs = decreased oxygen saturation | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = anti-GM-CSF antibodies, LDH elevated | |||
| Rads = airspace disease, "crazy paving" | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Pulmonary alveolar proteinosis''', abbreviated '''PAP''', in an uncommon [[medical lung diseases|medical lung disease]]. | '''Pulmonary alveolar proteinosis''', abbreviated '''PAP''', in an uncommon [[medical lung diseases|medical lung disease]]. | ||
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*Anti-GM-CSF antibodies - usually.<ref name=pmid16517574>{{Cite journal | last1 = Lin | first1 = FC. | last2 = Chang | first2 = GD. | last3 = Chern | first3 = MS. | last4 = Chen | first4 = YC. | last5 = Chang | first5 = SC. | title = Clinical significance of anti-GM-CSF antibodies in idiopathic pulmonary alveolar proteinosis. | journal = Thorax | volume = 61 | issue = 6 | pages = 528-34 | month = Jun | year = 2006 | doi = 10.1136/thx.2005.054171 | PMID = 16517574 }}</ref> | *Anti-GM-CSF antibodies - usually.<ref name=pmid16517574>{{Cite journal | last1 = Lin | first1 = FC. | last2 = Chang | first2 = GD. | last3 = Chern | first3 = MS. | last4 = Chen | first4 = YC. | last5 = Chang | first5 = SC. | title = Clinical significance of anti-GM-CSF antibodies in idiopathic pulmonary alveolar proteinosis. | journal = Thorax | volume = 61 | issue = 6 | pages = 528-34 | month = Jun | year = 2006 | doi = 10.1136/thx.2005.054171 | PMID = 16517574 }}</ref> | ||
*Serum LDH elevated.<ref name=pmid16517574/><ref name=pmid24532945>{{Cite journal | last1 = Bhattacharyya | first1 = D. | last2 = Barthwal | first2 = MS. | last3 = Katoch | first3 = CD. | last4 = Rohatgi | first4 = MG. | last5 = Hasnain | first5 = S. | last6 = Rai | first6 = SP. | last7 = Arora | first7 = A. | title = Primary alveolar proteinosis - A report of two cases. | journal = Med J Armed Forces India | volume = 69 | issue = 1 | pages = 90-3 | month = Jan | year = 2013 | doi = 10.1016/j.mjafi.2012.02.016 | PMID = 24532945 }}</ref> | *Serum LDH elevated.<ref name=pmid16517574/><ref name=pmid24532945>{{Cite journal | last1 = Bhattacharyya | first1 = D. | last2 = Barthwal | first2 = MS. | last3 = Katoch | first3 = CD. | last4 = Rohatgi | first4 = MG. | last5 = Hasnain | first5 = S. | last6 = Rai | first6 = SP. | last7 = Arora | first7 = A. | title = Primary alveolar proteinosis - A report of two cases. | journal = Med J Armed Forces India | volume = 69 | issue = 1 | pages = 90-3 | month = Jan | year = 2013 | doi = 10.1016/j.mjafi.2012.02.016 | PMID = 24532945 }}</ref> | ||
*Decreased oxygen saturation. | |||
===Radiology=== | ===Radiology=== | ||