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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Cervical squamous cell carcinoma in situ.jpg | |||
| Width = | |||
| Caption = Cervical squamous cell carcinoma in situ. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[squamous metaplasia of the uterine cervix]], [[high-grade squamous intraepithelial lesion]] | |||
| Stains = | |||
| IHC = p16 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = white lesion ~ usu. close to transformation zone | |||
| Grossing = | |||
| Site = [[uterine cervix]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = most common cervical malignancy | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usu. good, dependent on stage | |||
| Other = | |||
| ClinDDx = | |||
| Tx = cervical cone, radical hysterectomy | |||
}} | |||
'''Squamous cell carcinoma of the uterine cervix''', also '''cervical squamous cell carcinoma''', is the most common primary malignancy of the [[uterine cervix]]. | '''Squamous cell carcinoma of the uterine cervix''', also '''cervical squamous cell carcinoma''', is the most common primary malignancy of the [[uterine cervix]]. | ||
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*Nuclear atypia. | *Nuclear atypia. | ||
SCC of the cervix versus | SCC of the cervix versus [[high-grade squamous intraepithelial lesion]] (carcinoma in situ): | ||
Invasive cancer look for: | Invasive cancer look for: | ||
*Eosinophilia. | *Eosinophilia. | ||
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===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image:Cervical squamous cell carcinoma in situ.jpg|SCC in situ. (WC) | ||
</gallery> | </gallery> | ||
www: | www: | ||
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==IHC== | ==IHC== | ||
*CK7, p63, p16 +ve (except verrucous variant) | |||
*Factor VIII - to look for [[LVI]]. | *Factor VIII - to look for [[LVI]]. | ||
==Sign out== | ==Sign out== | ||
===Biopsy=== | |||
Early invasive SCC - things to report: | Early invasive SCC - things to report: | ||
*Depth of invasion. | *Depth of invasion. | ||
*Length of tumour. | *Length of tumour. | ||
*Number of blocks with tumour. | *Number of blocks with tumour. | ||
*LVI. | *[[Lymphovascular invasion]] (LVI). | ||
*Margins. | *Margins. | ||
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-- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED. | -- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED. | ||
-- LYMPHOVASCULAR INVASION NOT APPARENT. | -- LYMPHOVASCULAR INVASION NOT APPARENT. | ||
</pre> | |||
<pre> | |||
LESION, UTERINE CERVIX, BIOPSY: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, FRAGMENTED. | |||
- PLEASE SEE TUMOUR SUMMARY. | |||
TUMOUR SUMMARY - UTERINE CERVIX | |||
Specimen: Cervix. | |||
Procedure: Biopsy. | |||
Tumour Site: Cannot be determined. | |||
Tumour Size: Cannot be determined - see comment. | |||
Histologic Type: Squamous cell carcinoma, keratinizing. | |||
Histologic Grade: G2: Moderately differentiated. | |||
Stromal Invasion: Extent cannot be assessed - see comment. | |||
Lymph-Vascular Invasion: Not identified. | |||
Comment: | |||
The tissue submitted is essentially all tumour. The largest fragment measures 1.2 x 1.4 cm | |||
in the plane of section. Fragmentation and lack of normal histology preclude orientation. | |||
As both the in plane dimensions exceed 0.7 cm, this is at least a pT1b. | |||
</pre> | |||
===TAH-BSO=== | |||
<pre> | |||
UTERUS, CERVIX, RIGHT AND LEFT OVARIES AND BILATERAL UTERINE TUBES, TOTAL HYSTERECTOMY AND | |||
BILATERAL SALPINGO-OOPHORECTOMY: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA, pT1a1, pNx. | |||
-- MARGINS NEGATIVE FOR MALIGNANCY. | |||
-- PLEASE SEE TUMOUR SUMMARY. | |||
- PROLIFERATIVE ENDOMETRIUM. | |||
- UTERINE LEIOMYOMAS. | |||
- UTERINE TUBES WITH CHANGES COMPATIBLE WITH LIGATION, NO SIGNIFICANT PATHOLOGY. | |||
- OVARIES WITHOUT SIGNIFICANT PATHOLOGY. | |||
</pre> | </pre> | ||
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