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Difference between revisions of "Malignant melanoma"
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An internal review confirms the impression of at least melanoma in situ. | An internal review confirms the impression of at least melanoma in situ. | ||
</pre> | </pre> | ||
====Micro==== | ====Micro==== | ||
The sections show hair-bearing skin with atypical melanocytes confined to the epidermis. | The sections show hair-bearing skin with atypical melanocytes confined to the epidermis. | ||
The melanocytes scatter upwards (focally), have confluent growth and nucleoli, and involve | The melanocytes scatter upwards (focally), have confluent growth and nucleoli, and involve | ||
the adnexal structures. Occasional large multi-nucleated melanocytes, with their nuclei | the adnexal structures. Occasional large multi-nucleated melanocytes, with their nuclei | ||
arranged around the cell periphery, are present. Mitotic activity is not apparent. Extensive | arranged around the cell periphery, are present. Mitotic activity is not apparent. Extensive solar elastosis is present. | ||
solar elastosis is present. | |||
The lesion is very close to the margin (<0.1 mm clearance). | The lesion is very close to the margin (<0.1 mm clearance). | ||
===Invasive melanoma=== | |||
<pre> | |||
SKIN LESION, LEFT LOWER BACK, SHAVE BIOPSY: | |||
- INVASIVE MALIGNANT MELANOMA. | |||
-- AT LEAST pT3a. | |||
-- 6 MITOSES/MM*MM. | |||
-- DEEP AND LATERAL MARGINS POSITIVE, WIDE RE-EXCISION SHOULD BE DONE. | |||
-- PLEASE SEE TUMOUR SUMMARY. | |||
-- PLEASE SEE COMMENT. | |||
COMMENT: | |||
The morphologic impression is confirmed by immunostains; the tumour is POSITIVE for | |||
S-100, HMB-45,and MART-1). | |||
</pre> | |||
==See also== | ==See also== | ||