Difference between revisions of "Neuropathology tumours"

Neuropathology tumours (view source)

1,126 bytes removed , 03:13, 17 February 2014

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 *Commonly abbreviated ''AT/RT''.
 *May be written ''atypical teratoid rhabdoid tumour'', i.e. without the forward slash, or ''atypical teratoid-rhabdoid tumour'' (AT-RT).
+{{Main|Atypical teratoid/rhabdoid tumour}}
-===General===
-*Usually supratentorial, occasionally in posterior fossa, case reports of spinal cord.
-===Microscopic===
-Features:
-*Cellular.
-*Small round cells usu. with a prominent nucleolus.
-*Rhabdoid cells.
-**Cells with eosinophilic granular cytoplasm + eccentric nucleus.
-*Mitoses.
-*+/-[[Necrosis]] (common).
-DDx:
-*[[Primitive neuroectodermal tumour]] (PNET).
-*[[Medulloblastoma]].
-*[[Diffuse astrocytoma]].
-*[[Choroid plexus carcinoma]].
-*[[Embryonal carcinoma]].
-Images:
-*[http://commons.wikimedia.org/wiki/File:Rhabdoidtumourcell.jpg Rhabdoid tumour cell (WC)].
-*[http://commons.wikimedia.org/wiki/File:ATRT-HE-Overview.jpg AT/RT (WC)].
-*[http://commons.wikimedia.org/wiki/File:ATRT-INI1.jpg AT/RT -ve for INI1 (WC)].
-*[http://path.upmc.edu/cases/case99/micro.html AR/RT (upmc.edu)].
-===IHC===
-*BAF-47 -ve ([[AKA]] ''INI1'', [[AKA]] ''SMARCB1'' - the HGNC symbol<ref name=omim601607>{{OMIM|601607}}</ref>) - virtually diagnostic.
-**Endothelial cells +ve control.
-*S-100 +ve.
-**Few other brain tumours express it.
-*Vimentin +ve (perinuclear condensation).
-Others:
-*GFAP +ve (focal - in tumour cells).
-*EMA +ve (patchy cytoplasmic).
-*Smooth muscle actin +ve.
 ==Oligodendroglioma==