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Littoral cell angioma (view source)
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'''Littoral cell angioma''', abbreviated '''LCA''', is an uncommon benign [[vascular lesions|vascular lesion]] of the [[spleen]]. | |||
''Angioma'', in general, is dealt with in ''[[vascular malformations]]''. | |||
==General== | |||
Features:<ref name=pmid15329769>{{Cite journal | last1 = Tan | first1 = YM. | last2 = Chuah | first2 = KL. | last3 = Wong | first3 = WK. | title = Littoral cell angioma of the spleen. | journal = Ann Acad Med Singapore | volume = 33 | issue = 4 | pages = 524-6 | month = Jul | year = 2004 | doi = | PMID = 15329769 | url=http://www.annals.edu.sg/pdf200408/V33N4p524.pdf }}</ref> | |||
*Rare. | |||
*Benign. | |||
Clinical:<ref name=pmid15329769/><ref name=pmid11547761>{{Cite journal | last1 = Dascalescu | first1 = CM. | last2 = Wendum | first2 = D. | last3 = Gorin | first3 = NC. | title = Littoral-cell angioma as a cause of splenomegaly. | journal = N Engl J Med | volume = 345 | issue = 10 | pages = 772-3 | month = Sep | year = 2001 | doi = 10.1056/NEJM200109063451016 | PMID = 11547761 | url=http://www.nejm.org/doi/full/10.1056/NEJM200109063451016 }}</ref> | |||
*Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging. | |||
Note: | |||
*''Littoral cells'' = line vascular channels of the red pulp.<ref name=pmid15329769/> | |||
**''Littoral'' = related to ''shore''.<ref>URL: [http://www.merriam-webster.com/dictionary/littoral http://www.merriam-webster.com/dictionary/littoral]. Accessed on: 24 July 2011.</ref><ref>URL: [http://dictionary.reference.com/browse/littoral http://dictionary.reference.com/browse/littoral]. Accessed on: 24 July 2011.</ref> | |||
==Microscopic== | |||
Features:<ref name=pmid15329769/> | |||
*Anastoming, small vascular channels. | |||
*Cystic spaces. | |||
**May have papillary projections.<ref name=pmid11547761/> | |||
DDx:<ref name=pmid15329769/> | |||
*Vascular lesions: | |||
**[[Hemangioendothelioma]]. | |||
**[[Angiosarcoma]]. | |||
**[[Hemangiopericytoma]]. | |||
**[[Splenic hamartoma]]. | |||
===Images=== | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=5&Case=382 LCA - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=6&Case=382 LCA - high mag. (webpathology.com)]. | |||
<gallery> | |||
Image:Littoral_cell_angioma_of_the_spleen_-_very_low_mag.jpg | LCA - very low mag. (WC) | |||
Image:Littoral_cell_angioma_of_the_spleen_-_intermed_mag.jpg | LCA - intermed. mag. (WC) | |||
Image:Littoral_cell_angioma_of_the_spleen_-_very_high_mag.jpg | LCA - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=pmid15329769/> | |||
*CD68 +ve. | |||
*CD31 +ve | |||
Others: | |||
*CD34 -ve. | |||
*Factor VIII +ve. | |||
==See also== | |||
*[[Spleen]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Spleen]] | |||