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Collagenous spherulosis (view source)
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'''Collagenous spherulosis''' is a benign change of the [[breast]] that can be confused for a malignancy. | |||
It is also known as '''mucinous spherulosis''', and '''spherulosis'''.<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref> | |||
==General== | |||
*Benign. | |||
*Almost always an incidental finding. | |||
*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal | last1 = Resetkova | first1 = E. | last2 = Albarracin | first2 = C. | last3 = Sneige | first3 = N. | title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 20-7 | month = Jan | year = 2006 | doi = | PMID = 16330938 }}</ref> | |||
**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/> | |||
==Microscopic== | |||
Features:<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref><ref>URL: [http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm]. Accessed on: 31 August 2011.</ref> | |||
*Tubular/cribriform architecture. | |||
*Intratubular eosinophilic material - '''key feature'''. | |||
**Classical: Arranged like the spokes of a wheel ("radial spikes"). | |||
**Atypical: Granules ~ 1-2 micrometers. | |||
*No mitotic activity. | |||
*Two cells populations (epithelial & myoepithelial) - like a well-behaved breast gland. | |||
Notes: | |||
*Usually small lesions: < 50 spherules per lesion, <100 micrometers. | |||
*May be multifocal. | |||
*+/-Calcifications - may prompt biopsy. | |||
DDx: | |||
*[[Atypical ductal hyperplasia]]. | |||
*[[Cribriform DCIS]]. | |||
*[[Adenoid cystic carcinoma of the breast]]. | |||
===Images=== | |||
<gallery> | |||
Image:Collagenous_spherulosis_-_intermed_mag.jpg | Collagenous spherulosis - intermed. mag. (WC/Nephron) | |||
Image:Collagenous_spherulosis_-_high_mag.jpg | Collagenous spherulosis - high mag. (WC/Nephron) | |||
Image:Collagenous_spherulosis_-_very_high_mag.jpg | Collagenous spherulosis - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)]. | |||
==See also== | |||
*[[Breast pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Breast pathology]] | |||