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Difference between revisions of "Neuropathology"
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→Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Subcortical infarcts. | *+/-Subcortical infarcts. | ||
**Patches of (non-myelinated) tissue within the white matter deep to the cortex with abundant macrophages. | **Patches of (non-myelinated) tissue within the white matter deep to the cortex with abundant macrophages. | ||
*Blood vessels typically have a basophilic granularity.<ref name=pmid17076524>{{cite journal |author=Kleinschmidt-DeMasters BK, Prayson RA |title=An algorithmic approach to the brain biopsy--part I |journal=Arch. Pathol. Lab. Med. |volume=130 |issue=11 |pages=1630–8 |year=2006 |month=November |pmid=17076524 |doi= |url=}}</ref> | *Blood vessels typically have a basophilic granularity.<ref name=pmid17076524>{{cite journal |author=Kleinschmidt-DeMasters BK, Prayson RA |title=An algorithmic approach to the brain biopsy--part I |journal=Arch. Pathol. Lab. Med. |volume=130 |issue=11 |pages=1630–8 |year=2006 |month=November |pmid=17076524 |doi= |url=}}</ref> | ||
====IHC==== | |||
*Notch 3: smooth muscle and pericytes punctate +ve.<ref name=pmid12861102/> | |||
Note: | Note: | ||
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====Skin biopsy diagnosis==== | ====Skin biopsy diagnosis==== | ||
*Can be diagnosed on a skin biopsy. | *Can be diagnosed on a skin biopsy.<ref name=pmid11755616 >{{cite journal |author=Joutel A, Favrole P, Labauge P, ''et al.'' |title=Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis |journal=Lancet |volume=358 |issue=9298 |pages=2049–51 |year=2001 |month=December |pmid=11755616 |doi=10.1016/S0140-6736(01)07142-2 |url=}}</ref> | ||
===Electron microscopy=== | ===Electron microscopy=== | ||