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Difference between revisions of "Castleman disease"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Castleman_disease_-_high_mag.jpg | |||
| Width = | |||
| Caption = Castleman disease (hyaline-vascular variant). [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = hyaline-vascular variant (HVV), plasma cell variant (PCV) | |||
| LMDDx = HVV: [[mantle cell lymphoma]] | |||
| Stains = | |||
| IHC = HVV: cyclin D1 -ve, other stains to exclude lymphoma; PCV: HHV-8 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]] - see ''[[lymph node pathology]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Castleman disease''', abbreviated '''CD''', is a rare [[Lymph node pathology|pathology of the lymph node]]. | '''Castleman disease''', abbreviated '''CD''', is a rare [[Lymph node pathology|pathology of the lymph node]]. | ||
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==General== | ==General== | ||
*Benign. | *Benign. | ||
*Hyaline vascular variant - a pathology of the follicular dendritic cells.<ref>{{Cite journal | last1 = Cokelaere | first1 = K. | last2 = Debiec-Rychter | first2 = M. | last3 = De Wolf-Peeters | first3 = C. | last4 = Hagemeijer | first4 = A. | last5 = Sciot | first5 = R. | title = Hyaline vascular Castleman's disease with HMGIC rearrangement in follicular dendritic cells: molecular evidence of mesenchymal tumorigenesis. | journal = Am J Surg Pathol | volume = 26 | issue = 5 | pages = 662-9 | month = May | year = 2002 | doi = | PMID = 11979097 }}</ref> | *Hyaline vascular variant (classic Castleman disease) - a pathology of the follicular dendritic cells.<ref>{{Cite journal | last1 = Cokelaere | first1 = K. | last2 = Debiec-Rychter | first2 = M. | last3 = De Wolf-Peeters | first3 = C. | last4 = Hagemeijer | first4 = A. | last5 = Sciot | first5 = R. | title = Hyaline vascular Castleman's disease with HMGIC rearrangement in follicular dendritic cells: molecular evidence of mesenchymal tumorigenesis. | journal = Am J Surg Pathol | volume = 26 | issue = 5 | pages = 662-9 | month = May | year = 2002 | doi = | PMID = 11979097 }}</ref> | ||
===Classification=== | ===Classification=== | ||