Difference between revisions of "Neuropathology tumours"

Jump to navigation Jump to search

Neuropathology tumours (view source)

Revision as of 23:08, 8 November 2010

1,905 bytes removed ,  23:08, 8 November 2010
→‎Meningioma: split-out meningioma
(→‎Meningioma: split-out meningioma)
Line 155: Line 155:


==Meningioma==
==Meningioma==
{{Main|Meningioma}}
===General===
===General===
*Common.
*Very common.
*Extra-axial. (???)
*May be part of a syndrome.
*Most are benign.
**May be malignant.
*May be seen in genetic disorders such as [[neurofibromatosis]].<Ref>URL: [http://moon.ouhsc.edu/kfung/jty1/neurotest/Q13-Ans.htm http://moon.ouhsc.edu/kfung/jty1/neurotest/Q13-Ans.htm]. Accessed on: 26 October 2010.</ref>


===Microscopic===
===Microscopic===
Line 168: Line 166:
*Calcification.
*Calcification.


Many subtypes exist:
Grading: see ''[[meningioma]]''.
*Atypical meningioma.
**Has invasion of the brain - WHO Grade 2.
*Angiomatous meningioma.
*Others.
 
Images:
*[http://commons.wikimedia.org/wiki/File:Meningioma_high_mag.jpg Meningioma - high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Meningioma_intermed_mag.jpg Meningioma - intermed. mag. (WC)].
*[http://www.neuropathologyweb.org/chapter7/chapter7dMiscellaneous.html Meningioma (neuropathologyweb.org)].
 
DDx:
*Cerebral angioid angiopathy. (???)
 
Notes:
*May involute into benign sclerotic tissue.<ref>URL: [http://radiographics.rsna.org/content/23/3/785.long http://radiographics.rsna.org/content/23/3/785.long]. Accessed on: 3 November 2010.</ref>
 
====Histomorphologic grading====
Grading:<ref name=Ref_PSNP194>{{Ref PSNP|194}}</ref>
*Grade 1:
**Low mitotic rate.
**Excludes ''clear cell'', ''chordoid'', ''papillary'', and ''rhabdoid'' subtypes.
*Grade 2 (either #1 or #2):
*#Brain-invasive meningioma.
*#*Protrusion of meningioma into brain.
*#**Meninogioma with entraped GFAP +ve tissue.
*#Atypical meningioma (by histomorphology).
*#*Intermediate mitotic rate (>= 4 mitoses/10 HPF - for whatever ''HPF'' means, see [[HPFitis]].)
*#*Three of the following five features:
*#*#Sheeting architecture.
*#*#High NC ratio clusters; clusters of "lymphocyte-like" cells.
*#*#Hypercellularity.
*#*#Macronucleoli.
*#*#Necrosis not caused by treatment, e.g. radiation or embolization.
*Grade 3 (either of the following):
**High mitotic rate (>=20 mitoses/10 HPF - for whatever ''HPF'' means, see [[HPFitis]].)
**"Frank anaplasia"; marked nuclear atypia.
 
hypercell
necrosis, NC ratio,
macronuc
 
===IHC===
*EMA +ve.<ref name=Ref_PSNP13>{{Ref PSNP|13}}</ref>
**Other CKs usu. -ve.


==Schwannoma==
==Schwannoma==
Michael
48,830

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/2600"

Navigation menu