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Difference between revisions of "Primary biliary cholangitis"
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Primary biliary cholangitis (view source)
Revision as of 22:12, 11 November 2013
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Primary_biliary_cirrhosis_low_mag.jpg | |||
| Width = | |||
| Caption = Primary biliary cirrhosis. [[H&E stain]]. | |||
| Micro = "Florid duct lesion": intraepithelial lymphocytes - in bile duct, bile duct epithelial cells with eosinophilic cytoplasm; plasma cells; +/-[[granulomas]] (close to bile duct); "Garland" cirrhosis -- has irregular border | |||
| Subtypes = | |||
| LMDDx = [[sarcoidosis]], [[primary sclerosing cholangitis]], [[viral hepatitis]], [[autoimmune hepatitis]], [[drug-induced liver disease]], [[Hodgkin's lymphoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[liver]] - see [[medical liver diseases]] | |||
| Assdx = other autoimmune conditions, e.g. [[celiac disease]], [[Sjögren syndrome]] | |||
| Syndromes = | |||
| Clinicalhx = woman, middle age | |||
| Signs = | |||
| Symptoms = pruritis | |||
| Prevalence = | |||
| Bloodwork = AMA +ve | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Primary biliary cirrhosis''', abbreviated '''PBC''', is a rare [[medical liver disease]]. | '''Primary biliary cirrhosis''', abbreviated '''PBC''', is a rare [[medical liver disease]]. | ||
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*[[Sarcoidosis]] (if granulomas present). | *[[Sarcoidosis]] (if granulomas present). | ||
*[[Primary sclerosing cholangitis]]. | *[[Primary sclerosing cholangitis]]. | ||
*Viral hepatitis. | *[[Viral hepatitis]]. | ||
*[[Autoimmune hepatitis]]. | *[[Autoimmune hepatitis]]. | ||
* | *[[Drug-induced liver disease]]. | ||
*[[Hodgkin's lymphoma]].<ref name=pmid19131796>Vanishing bile duct syndrome and Hodgkin disease: a case series and review of the literature. Pass AK, McLin VA, Rushton JR, Kearney DL, Hastings CA, Margolin JF. J Pediatr Hematol Oncol. 2008 Dec;30(12):976-80. PMID 19131796.</ref> | *[[Hodgkin's lymphoma]].<ref name=pmid19131796>Vanishing bile duct syndrome and Hodgkin disease: a case series and review of the literature. Pass AK, McLin VA, Rushton JR, Kearney DL, Hastings CA, Margolin JF. J Pediatr Hematol Oncol. 2008 Dec;30(12):976-80. PMID 19131796.</ref> | ||