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Difference between revisions of "Neuropathology tumours"
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→Histomorphologic grading
(→Meningioma: fix classification) |
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====Histomorphologic grading==== | ====Histomorphologic grading==== | ||
Grading:<ref name=Ref_PSNP194>{{Ref PSNP|194}}</ref> | Grading:<ref name=Ref_PSNP194>{{Ref PSNP|194}}</ref> | ||
*Grade 1: | *Grade 1: | ||
**Low mitotic rate. | **Low mitotic rate. | ||
*Grade 2: | **Excludes ''clear cell'', ''chordoid'', ''papillary'', and ''rhabdoid'' subtypes. | ||
* | *Grade 2 (either #1 or #2): | ||
* | *#Brain-invasive meningioma. | ||
* | *#*Protrusion of meningioma into brain. | ||
* | *#**Meninogioma with entraped GFAP +ve tissue. | ||
* | *#Atypical meningioma (by histomorphology). | ||
* | *#*Intermediate mitotic rate (>= 4 mitoses/10 HPF - for whatever ''HPF'' means, see [[HPFitis]].) | ||
* | *#*Three of the following five features: | ||
* | *#*#Sheeting architecture. | ||
* | *#*#High NC ratio clusters; clusters of "lymphocyte-like" cells. | ||
* | *#*#Hypercellularity. | ||
* | *#*#Macronucleoli. | ||
*Grade 3: | *#*#Necrosis not caused by treatment, e.g. radiation or embolization. | ||
*Grade 3 (either of the following): | |||
**High mitotic rate (>=20 mitoses/10 HPF - for whatever ''HPF'' means, see [[HPFitis]].) | **High mitotic rate (>=20 mitoses/10 HPF - for whatever ''HPF'' means, see [[HPFitis]].) | ||
**"Frank anaplasia"; marked nuclear atypia. | **"Frank anaplasia"; marked nuclear atypia. | ||
hypercell | |||
necrosis, NC ratio, | |||
macronuc | |||
===IHC=== | ===IHC=== | ||