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Difference between revisions of "Neuropathology tumours"
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→Meningioma: grading
(→Brain tumours: primary vs. secondary - more) |
(→Meningioma: grading) |
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| Line 174: | Line 174: | ||
DDx: | DDx: | ||
*Cerebral angioid angiopathy. (???) | *Cerebral angioid angiopathy. (???) | ||
====Histomorpholic grading==== | |||
Grading:<ref name=Ref_PSNP194>{{Ref PSNP|194}}</ref>: | |||
*Grade 1: | |||
**Low mitotic rate. | |||
*Grade 2: | |||
**Intermediate mitotic rate (>= 4 mitoses/HPF - for whatever ''HPF'' means, see [[HPFitis]].) | |||
**Three of the following five features: | |||
**#Sheeting architecture. | |||
**#High NC ratio; clusters of "lymphocyte-like" cells. | |||
**#Hypercellularity. | |||
**#Macronucleoli. | |||
**#Necrosis not caused by treatment, e.g. radiation or embolization. | |||
*Grade 3: | |||
**High mitotic rate (>=20 mitoses/HPF - for whatever ''HPF'' means, see [[HPFitis]].) | |||
**"Frank anaplasia"; marked nuclear atypia. | |||
===IHC=== | ===IHC=== | ||