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Epithelial-myoepithelial carcinoma (view source)
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# | Epithelial-myoepithelial carcinoma, abbreviated '''EMCa''', is a rare malignant [[salivary gland]] tumour. | ||
==General== | |||
*Rare ~1% of salivary gland tumours.<ref name=pmid9568184>{{Cite journal | last1 = Tralongo | first1 = V. | last2 = Daniele | first2 = E. | title = Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. | journal = Anticancer Res | volume = 18 | issue = 1B | pages = 603-8 | month = | year = | doi = | PMID = 9568184 }}</ref> | |||
*Female:male = 1.5:1.<ref name=pmid17197918>{{Cite journal | last1 = Seethala | first1 = RR. | last2 = Barnes | first2 = EL. | last3 = Hunt | first3 = JL. | title = Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. | journal = Am J Surg Pathol | volume = 31 | issue = 1 | pages = 44-57 | month = Jan | year = 2007 | doi = 10.1097/01.pas.0000213314.74423.d8 | PMID = 17197918 }}</ref> | |||
*Usu. older people - 50s or 60s. | |||
*Usu. parotid gland ~ 60% of cases.<ref name=pmid17197918/> | |||
*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/> | |||
Notes: | |||
*Most common malignant component in ''[[carcinoma ex pleomorphic adenoma]]''. | |||
*May be the same tumour as ''[[adenomyoepithelioma]] of the breast''.<ref name=pmid9769134>{{Cite journal | last1 = Seifert | first1 = G. | title = Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? | journal = Virchows Arch | volume = 433 | issue = 3 | pages = 285-8 | month = Sep | year = 1998 | doi = | PMID = 9769134 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Biphasic tumour:<ref name=pmid17197918/> | |||
*#Epithelial layer. | |||
*#Myoepithelial layer - '''key feature'''. | |||
*Architecture: variable (solid, cystic, tubular, papillary). | |||
*+/-Spindle cells. | |||
*Basement membrane-like material; may mimic adenoid cystic carcinoma. | |||
Notes: | |||
*Usually few mitoses. | |||
DDx: | |||
*[[Adenoid cystic carcinoma]] (tubular variant). | |||
*[[Pleomorphic adenoma]], tubular variant. | |||
**Has focal epithelial-myoepithelial carcinoma-like areas. | |||
===Images=== | |||
<gallery> | |||
Image:Epithelial-myoepithelial_carcinoma_-_intermed_mag.jpg | EMCa - intermed. mag. (WC/Nephron) | |||
Image:Epithelial-myoepithelial_carcinoma_-_high_mag.jpg | EMCa - high mag. (WC/Nephron) | |||
Image:Epithelial-myoepithelial carcinoma - very high mag.jpg | EMCa - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/images-features/emc-rev-cyto1-18.jpg EMCa (pathologyimagesinc.com)].<ref>{{cite web |url=http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/fs-emc-cytopath-feat.html |title=Cytopathologic Features of | |||
Epithelial-myoepithelial Carcinoma |last1= |first1= |last2= |first2= |date= |work= |publisher= |accessdate=January 18, 2011}}</ref> | |||
*[http://www.headandneckoncology.org/content/2/1/4 EMCa (headandneckoncology.org)]. | |||
==IHC== | |||
*CAM5.2 +ve -- epithelial component. | |||
*p63 +ve -- myoepithelial component. | |||
==See also== | |||
*[[Salivary glands]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary gland]] | |||
[[Category:Head and neck pathology]] | |||