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Difference between revisions of "Acinic cell carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Acinic_cell_carcinoma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Acinic cell carcinoma. [[H&E stain]]. | |||
| Micro = "acinic cells" (abundant finely vacuolated cytoplasm with basophilic granules, small nuclei with stippled chromatin), scattered "intercalcated duct type cells" (eosinophilic cytoplasm with moderate amount of cytoplasm and bland nuclei), +/-peri-tumoural lymphocytes. | |||
*+/-glassy extracellular bluish/purple blobs | |||
| Subtypes = oncocytic variant, clear cell variant, papillary cystic variant | |||
| LMDDx = [[oncocytoma of the salivary gland]], [[mucoepidermoid carcinoma]], adenocarcinoma NOS | |||
| Stains = PAS +ve, PASD +ve | |||
| IHC = p63 -ve, S-100 -ve | |||
| EM = [[zymogen granules]] | |||
| Molecular = | |||
| IF = | |||
| Gross = tan or reddish | |||
| Grossing = | |||
| Site = [[salivary gland]] - usu. parotid gland | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = salivary gland mass | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Acinic cell carcinoma''', abbreviated '''AcCC''', is a rare type of [[salivary gland]] cancer. It is also known as '''acinic cell adenocarcinoma'''. | '''Acinic cell carcinoma''', abbreviated '''AcCC''', is a rare type of [[salivary gland]] cancer. It is also known as '''acinic cell adenocarcinoma'''. | ||
| Line 71: | Line 101: | ||
*S-100 -ve. | *S-100 -ve. | ||
*p63 -ve. | *p63 -ve. | ||
**p63 +ve in mucoepidermoid carcinoma. | **p63 +ve in [[mucoepidermoid carcinoma]]. | ||
There are a bunch of other [[stains]] that are touted to be useful (amylase, anti-chymotrypsin, lactoferrin). Weinreb thinks these are '''not''' helpful.<ref name=IW_10jan2011>IW. 11 January 2011.</ref> | There are a bunch of other [[stains]] that are touted to be useful (amylase, anti-chymotrypsin, lactoferrin). Weinreb thinks these are '''not''' helpful.<ref name=IW_10jan2011>IW. 11 January 2011.</ref> | ||