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Difference between revisions of "Warthin tumour"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Papillary_cystadenoma_lymphomatosum2.jpg | |||
| Width = | |||
| Caption = Warthin tumour. [[H&E stain]]. | |||
| Micro = papillae with a two rows of pink (eosinophilic) epithelial cells (with cuboidal basal cells and columnar luminal cells), fibrous capsule, cystic space filled with debris, lymphoid stroma | |||
| Subtypes = | |||
| LMDDx = lymphoepithelial cyst. | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[salivary gland]] - parotid gland only | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = strong association of smoking | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good, benign | |||
| Other = | |||
| ClinDDx = other [[salivary gland]] tumours | |||
}} | |||
'''Warthin tumour''' is a relative common benign tumour of the parotid gland. It is also known as '''papillary cystadenoma lymphomatosum'''. | |||
===General=== | |||
Epidemiology: | |||
*May be multicentric ~ 15% of the time. | |||
*May be bilateral ~10% of the time. | |||
*Classically: male > female -- changing with more women smokers. | |||
*Smokers. | |||
*Old - usu. 60s, very rarely < 40 years old. | |||
Notes: | |||
*No malignant transformation. | |||
*Not in submandibular gland. | |||
*Not in sublingual gland. | |||
*Not in children. | |||
===Gross=== | |||
*Motor-oil like fluid. | |||
*Cystic component larger in larger lesions. | |||
**Small lesions may be solid. | |||
Image: | |||
*[http://www.flickr.com/photos/bc_the_path/2510239905/in/photostream/ Warthin tumour (flickr.com)]. | |||
===Microscopic=== | |||
Features: | |||
* Papillae (nipple-shaped structures) with a two rows of pink (eosinophilic) epithelial cells (with cuboidal basal cells and columnar luminal cells) -- '''key feature'''. | |||
* Fibrous capsule - pink & homogenous on [[H&E stain]]. | |||
* Cystic space filled with debris ''in situ'' (not [[necrosis]]). | |||
* Lymphoid stroma. | |||
Notes: | |||
*+/-Squamous differentiation. | |||
*+/-Goblet cell differentiation. | |||
DDx: | |||
*Lymphoepithelial cyst. | |||
**Cyst within a lymph node. | |||
===Images=== | |||
<gallery> | |||
Image:Papillary_cystadenoma_lymphomatosum3.jpg | Warthin tumour - high mag. (WC/Nephron) | |||
Image:Papillary_cystadenoma_lymphomatosum2.jpg | Warthin tumour - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
==See also== | |||
*[[Salivary glands]]. | |||
*[[Head and neck pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary glands]] | |||
[[Category:Head and neck pathology]] | |||